ID   A2A2N0_HUMAN            Unreviewed;       134 AA.
AC   A2A2N0;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   05-DEC-2018, entry version 90.
DE   RecName: Full=Cystatin {ECO:0000256|RuleBase:RU362130};
DE   Flags: Fragment;
GN   Name=CST8 {ECO:0000313|Ensembl:ENSP00000399144};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000399144, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000399144, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000399144}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the cystatin family.
CC       {ECO:0000256|RuleBase:RU362130, ECO:0000256|SAAS:SAAS00722218}.
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DR   EMBL; AL109954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A2A2N0; -.
DR   PeptideAtlas; A2A2N0; -.
DR   Ensembl; ENST00000449810; ENSP00000399144; ENSG00000125815.
DR   UCSC; uc061vvu.1; human.
DR   EuPathDB; HostDB:ENSG00000125815.8; -.
DR   HGNC; HGNC:2480; CST8.
DR   OpenTargets; ENSG00000125815; -.
DR   eggNOG; ENOG410IXH4; Eukaryota.
DR   eggNOG; ENOG41113F6; LUCA.
DR   GeneTree; ENSGT00940000162294; -.
DR   HOGENOM; HOG000231754; -.
DR   HOVERGEN; HBG095685; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000125815; Expressed in 12 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; A2A2N0; baseline and differential.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR027214; Cystatin.
DR   InterPro; IPR000010; Cystatin_dom.
DR   PANTHER; PTHR11413; PTHR11413; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   SMART; SM00043; CY; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Protease inhibitor {ECO:0000256|RuleBase:RU362130};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A2A2N0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU362130};
KW   Thiol protease inhibitor {ECO:0000256|RuleBase:RU362130}.
FT   SIGNAL        1     19       {ECO:0000256|RuleBase:RU362130}.
FT   CHAIN        20    134       Cystatin.
FT                                {ECO:0000256|RuleBase:RU362130}.
FT                                /FTId=PRO_5005395954.
FT   DOMAIN       30    131       Cystatin. {ECO:0000259|SMART:SM00043}.
FT   NON_TER     134    134       {ECO:0000313|Ensembl:ENSP00000399144}.
SQ   SEQUENCE   134 AA;  15340 MW;  732F3759BE150659 CRC64;
     MPRCRWLSLI LLTIPLALVA RKDPKKNETG VLRKLKPVNA SNANVKQCLW FAMQEYNKES
     EDKYVFLVVK TLQAQLQVTN LLEYLIDVEI ARSDCRKPLS TNEICAIQEN SKLKRKLSCS
     FLVGALPWNG EFTV
//