ID   A2A2G4_HUMAN            Unreviewed;       509 AA.
AC   A2A2G4;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 91.
DE   RecName: Full=Alpha-1,3-glucosyltransferase {ECO:0000256|RuleBase:RU363110};
DE            EC=2.4.1.- {ECO:0000256|RuleBase:RU363110};
GN   Name=ALG6 {ECO:0000313|Ensembl:ENSP00000263440};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000263440, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000263440, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000263440}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|RuleBase:RU363110}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU363110}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363110}.
CC   -!- SIMILARITY: Belongs to the ALG6/ALG8 glucosyltransferase family.
CC       {ECO:0000256|RuleBase:RU363110}.
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DR   EMBL; AL049636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL592218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A2A2G4; -.
DR   EPD; A2A2G4; -.
DR   jPOST; A2A2G4; -.
DR   MaxQB; A2A2G4; -.
DR   PeptideAtlas; A2A2G4; -.
DR   PRIDE; A2A2G4; -.
DR   Ensembl; ENST00000263440; ENSP00000263440; ENSG00000088035.
DR   UCSC; uc057hek.1; human.
DR   EuPathDB; HostDB:ENSG00000088035.15; -.
DR   HGNC; HGNC:23157; ALG6.
DR   OpenTargets; ENSG00000088035; -.
DR   eggNOG; KOG2575; Eukaryota.
DR   eggNOG; ENOG410XQK1; LUCA.
DR   HOGENOM; HOG000195048; -.
DR   HOVERGEN; HBG024331; -.
DR   OMA; YLPCFTF; -.
DR   PhylomeDB; A2A2G4; -.
DR   UniPathway; UPA00378; -.
DR   ChiTaRS; ALG6; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000088035; Expressed in 205 organ(s), highest expression level in secondary oocyte.
DR   ExpressionAtlas; A2A2G4; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042281; F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity; IEA:InterPro.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR039488; ALG6.
DR   InterPro; IPR004856; Glyco_trans_ALG6/ALG8.
DR   PANTHER; PTHR12413; PTHR12413; 1.
DR   PANTHER; PTHR12413:SF1; PTHR12413:SF1; 1.
DR   Pfam; PF03155; Alg6_Alg8; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU363110};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU363110};
KW   Membrane {ECO:0000256|RuleBase:RU363110};
KW   Proteomics identification {ECO:0000213|EPD:A2A2G4,
KW   ECO:0000213|MaxQB:A2A2G4, ECO:0000213|PeptideAtlas:A2A2G4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|RuleBase:RU363110};
KW   Transmembrane {ECO:0000256|RuleBase:RU363110};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363110}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    509       Alpha-1,3-glucosyltransferase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002642143.
FT   TRANSMEM    110    132       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    144    164       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    176    199       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    229    251       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    300    320       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    350    373       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    388    410       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    431    459       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    471    497       Helical. {ECO:0000256|RuleBase:RU363110}.
SQ   SEQUENCE   509 AA;  58348 MW;  7A69FCBA5AB8228D CRC64;
     MEKWYLMTVV VLIGLTVRWT VSLNSYSGAG KPPMFGDYEA QRHWQEITFN LPVKQWYFNS
     SDNNLQYWGL DYPPLTAYHS LLCAYVAKFI NPDWIALHTS RGYESQAHKL FMRTTVLIAD
     LLIYIPAVVL YCCCLKEIST KKKIANALCI LLYPGLILID YGHFQNIYNS VSLGFALWGV
     LGISCDCDLL GSLAFCLAIN YKQMELYHAL PFFCFLLGKC FKKGLKGKGF VLLVKLACIV
     VASFVLCWLP FFTEREQTLQ VLRRLFPVDR GLFEDKVANI WCSFNVFLKI KDILPRHIQL
     IMSFCSTFLS LLPACIKLIL QPSSKGFKFT LVSCALSFFL FSFQVHEKSI LLVSLPVCLV
     LSEIPFMSTW FLLVSTFSML PLLLKDELLM PSVVTTMAFF IACVTSFSIF EKTSEEELQL
     KSFSISVRKY LPCFTFLSRI IQYLFLISVI TMVLLTLMTV TLDPPQKLPD LFSVLVCFVS
     CLNFLFFLVY FNIIIMWDSK SGRNQKKIS
//