ID   SHSA3_HUMAN             Reviewed;         238 AA.
AC   A0PJX4; A0PJX3; Q96EQ5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   13-FEB-2019, entry version 88.
DE   RecName: Full=Protein shisa-3 homolog;
DE   Flags: Precursor;
GN   Name=SHISA3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-13.
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays an essential role in the maturation of presomitic
CC       mesoderm cells by individual attenuation of both FGF and WNT
CC       signaling. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8ND90:PNMA1; NbExp=3; IntAct=EBI-10171518, EBI-302345;
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250,
CC       ECO:0000250|UniProtKB:Q7T0Z7}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q7T0Z7}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; CH471069; EAW93002.1; -; Genomic_DNA.
DR   EMBL; BC012029; AAH12029.1; -; mRNA.
DR   EMBL; BC127690; AAI27691.1; -; mRNA.
DR   EMBL; BC127691; AAI27692.1; -; mRNA.
DR   CCDS; CCDS33979.1; -.
DR   RefSeq; NP_001073974.1; NM_001080505.1.
DR   UniGene; Hs.370904; -.
DR   ProteinModelPortal; A0PJX4; -.
DR   SMR; A0PJX4; -.
DR   BioGrid; 127452; 13.
DR   IntAct; A0PJX4; 2.
DR   iPTMnet; A0PJX4; -.
DR   PhosphoSitePlus; A0PJX4; -.
DR   BioMuta; SHISA3; -.
DR   PaxDb; A0PJX4; -.
DR   PRIDE; A0PJX4; -.
DR   ProteomicsDB; 68; -.
DR   Ensembl; ENST00000319234; ENSP00000326445; ENSG00000178343.
DR   GeneID; 152573; -.
DR   KEGG; hsa:152573; -.
DR   UCSC; uc003gwp.3; human.
DR   CTD; 152573; -.
DR   DisGeNET; 152573; -.
DR   EuPathDB; HostDB:ENSG00000178343.4; -.
DR   GeneCards; SHISA3; -.
DR   HGNC; HGNC:25159; SHISA3.
DR   HPA; HPA054754; -.
DR   MIM; 617325; gene.
DR   neXtProt; NX_A0PJX4; -.
DR   OpenTargets; ENSG00000178343; -.
DR   PharmGKB; PA162403293; -.
DR   eggNOG; ENOG410IF26; Eukaryota.
DR   eggNOG; ENOG4111FHU; LUCA.
DR   GeneTree; ENSGT00940000161360; -.
DR   HOGENOM; HOG000234350; -.
DR   HOVERGEN; HBG059385; -.
DR   InParanoid; A0PJX4; -.
DR   OMA; TWNLRIS; -.
DR   OrthoDB; 1325567at2759; -.
DR   PhylomeDB; A0PJX4; -.
DR   TreeFam; TF330800; -.
DR   GenomeRNAi; 152573; -.
DR   PRO; PR:A0PJX4; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000178343; Expressed in 132 organ(s), highest expression level in metanephros.
DR   Genevisible; A0PJX4; HS.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395; PTHR31395; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; Endoplasmic reticulum;
KW   Membrane; Polymorphism; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22    238       Protein shisa-3 homolog.
FT                                /FTId=PRO_0000330025.
FT   TOPO_DOM     22     98       Lumenal. {ECO:0000305}.
FT   TRANSMEM     99    119       Helical. {ECO:0000255}.
FT   TOPO_DOM    120    238       Cytoplasmic. {ECO:0000305}.
FT   COMPBIAS    190    195       Poly-Pro.
FT   VARIANT      13     13       W -> C (in dbSNP:rs11733156).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_042687.
FT   CONFLICT     95     95       V -> G (in Ref. 2; AAH12029).
FT                                {ECO:0000305}.
SQ   SEQUENCE   238 AA;  25832 MW;  8469E3758F61D22C CRC64;
     MRALLALCLL LGWLRWGPAG AQQSGEYCHG WVDVQGNYHE GFQCPEDFDT LDATICCGSC
     ALRYCCAAAD ARLEQGGCTN DRRELEHPGI TAQPVYVPFL IVGSIFIAFI ILGSVVAIYC
     CTCLRPKEPS QQPIRFSLRS YQTETLPMIL TSTSPRAPSR QSSTATSSSS TGGSIRRFSF
     ARAEPGCLVP SPPPPYTTSH SIHLAQPSGF LVSPQYFAYP LQQEPPLPGK SCPDFSSS
//