ID   A0A5B4_HUMAN            Unreviewed;       111 AA.
AC   A0A5B4;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   SubName: Full=T cell receptor beta variable 20-1 {ECO:0000313|Ensembl:ENSP00000488099};
DE   SubName: Full=V_segment translation product {ECO:0000313|EMBL:AAC13343.1};
DE   Flags: Fragment;
GN   Name=TRBV20-1 {ECO:0000313|Ensembl:ENSP00000488099};
GN   Synonyms=TCRBV2S1 {ECO:0000313|EMBL:AAC13343.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAC13343.1};
RN   [1] {ECO:0000313|EMBL:AAC13343.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8020962; DOI=10.1006/geno.1994.1149;
RA   Slightom J.L., Siemieniak D.R., Sieu L.C., Koop B.F., Hood L.;
RT   "Nucleotide sequence analysis of 77.7 kb of the human V beta T-cell
RT   receptor gene locus: direct primer-walking using cosmid template
RT   DNAs.";
RL   Genomics 20:149-168(1994).
RN   [2] {ECO:0000313|EMBL:AAC13343.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8650574; DOI=10.1126/science.272.5269.1755;
RA   Rowen L., Koop B.F., Hood L.;
RT   "The complete 685-kilobase DNA sequence of the human beta T cell
RT   receptor locus.";
RL   Science 272:1755-1762(1996).
RN   [3] {ECO:0000313|EMBL:AAC13343.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Rowen L., Seto J., Smit A., Acharya C., Ahearn M.E., Ankener M.,
RA   Baskin D., Bumgarner R., Chen L., Chen N., Deshpande P., Faust J.,
RA   Howard S., Jerome N., Koop B.F., Lee H., Loretz C., Paeper B.,
RA   Zackrone K., Hood L.;
RT   "Sequence determination of the human T cell receptor beta locus:
RT   Strategy and error analysis.";
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAC13343.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Rowen L., Wang K., Boysen C., Ahearn M.E., Charmley P., Paeper B.,
RA   Lee I., Chen L., Trask B., Nickerson D., Seto D., Hood L.;
RT   "Sequence variation among several haplotypes in the human T cell
RT   receptor beta locus.";
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Ensembl:ENSP00000488099}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [6] {ECO:0000213|PDB:2IJ0}
RP   X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 15-110, AND DISULFIDE BONDS.
RX   PubMed=17268555; DOI=10.1038/sj.emboj.7601531;
RA   Moza B., Varma A.K., Buonpane R.A., Zhu P., Herfst C.A.,
RA   Nicholson M.J., Wilbuer A.K., Seth N.P., Wucherpfennig K.W.,
RA   McCormick J.K., Kranz D.M., Sundberg E.J.;
RT   "Structural basis of T-cell specificity and activation by the
RT   bacterial superantigen TSST-1.";
RL   EMBO J. 26:1187-1197(2007).
RN   [7] {ECO:0000213|PDB:3MFG}
RP   X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 15-110, AND DISULFIDE BONDS.
RA   Bonsor D.A., Sundberg E.J.;
RT   "Crystal structure of Toxic Shock Syndrome Toxin 1 (TSST-1) in complex
RT   with the human T cell receptor beta chain Vbeta2.1 (EP-8).";
RL   Submitted (APR-2010) to the PDB data bank.
RN   [8] {ECO:0000313|Ensembl:ENSP00000488099}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
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DR   EMBL; AC239612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; L36092; AAC13343.1; -; Genomic_DNA.
DR   PIR; S26255; S26255.
DR   PDB; 2IJ0; X-ray; 2.25 A; C/E=15-110.
DR   PDB; 3MFG; X-ray; 2.37 A; B=15-110.
DR   PDBsum; 2IJ0; -.
DR   PDBsum; 3MFG; -.
DR   SMR; A0A5B4; -.
DR   BioMuta; TRBV20-1; -.
DR   Ensembl; ENST00000633466; ENSP00000488099; ENSG00000282064.
DR   HGNC; HGNC:12196; TRBV20-1.
DR   HOGENOM; HOG000197709; -.
DR   OrthoDB; 1522235at2759; -.
DR   ChiTaRS; TRBV20-1; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:2IJ0, ECO:0000213|PDB:3MFG};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A5B4,
KW   ECO:0000213|PeptideAtlas:A0A5B4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    111       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014564941.
FT   DOMAIN       30    111       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DISULFID     37    108       {ECO:0000213|PDB:2IJ0,
FT                                ECO:0000213|PDB:3MFG}.
FT   NON_TER     111    111       {ECO:0000313|EMBL:AAC13343.1,
FT                                ECO:0000313|Ensembl:ENSP00000488099}.
SQ   SEQUENCE   111 AA;  12205 MW;  DD52696FC83EF978 CRC64;
     MLLLLLLLGP GSGLGAVVSQ HPSWVICKSG TSVKIECRSL DFQATTMFWY RQFPKQSLML
     MATSNEGSKA TYEQGVEKDK FLINHASLTL STLTVTSAHP EDSSFYICSA R
//