ID   A0A3B3ITM1_HUMAN        Unreviewed;       175 AA.
AC   A0A3B3ITM1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   13-FEB-2019, entry version 3.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSP00000497835};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSP00000497835};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000497835, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000497835, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000497835}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2018) to UniProtKB.
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DR   EMBL; AC024168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000647685; ENSP00000497835; ENSG00000150995.
DR   Ensembl; ENST00000649139; ENSP00000497226; ENSG00000150995.
DR   Ensembl; ENST00000649908; ENSP00000497614; ENSG00000150995.
DR   HGNC; HGNC:6180; ITPR1.
DR   OpenTargets; ENSG00000150995; -.
DR   GeneTree; ENSGT00940000155071; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A3B3ITM1,
KW   ECO:0000213|MaxQB:A0A3B3ITM1, ECO:0000213|PeptideAtlas:A0A3B3ITM1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    175       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017151704.
FT   COILED      113    154       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   175 AA;  20443 MW;  883BD5670083117F CRC64;
     MVIIIVLNLI FGVIIDTFAD LRSEKQKKEE ILKTTCFICG LERDKFDNKT VTFEEHIKEE
     HNMWHYLCFI VLVKVKDSTE YTGPESYVAE MIKERNLDWF PRMRAMSLVS SDSEGEQNEL
     RNLQEKLEST MKLVTNLSGQ LSELKDQMTE QRKQKQRIGL LGHPPHMNVN PQQPA
//