ID   A0A3B3ITK0_HUMAN        Unreviewed;      1177 AA.
AC   A0A3B3ITK0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   13-FEB-2019, entry version 3.
DE   SubName: Full=Thrombospondin-2 {ECO:0000313|Ensembl:ENSP00000497834};
GN   Name=THBS2 {ECO:0000313|Ensembl:ENSP00000497834};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000497834, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000497834, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000497834}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; BX322234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000649844; ENSP00000497834; ENSG00000186340.
DR   HGNC; HGNC:11786; THBS2.
DR   OpenTargets; ENSG00000186340; -.
DR   GeneTree; ENSGT00940000157846; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 3.
DR   Gene3D; 4.10.1080.10; -; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR037349; Thrombospondin.
DR   InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR   InterPro; IPR017897; Thrombospondin_3_rpt.
DR   InterPro; IPR008859; Thrombospondin_C.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR015455; TSP2.
DR   InterPro; IPR028974; TSP_type-3_rpt.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR10199; PTHR10199; 2.
DR   PANTHER; PTHR10199:SF10; PTHR10199:SF10; 2.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF00090; TSP_1; 3.
DR   Pfam; PF02412; TSP_3; 7.
DR   Pfam; PF05735; TSP_C; 1.
DR   Pfam; PF00093; VWC; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00209; TSP1; 3.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00214; VWC; 1.
DR   SUPFAM; SSF103647; SSF103647; 3.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82895; SSF82895; 3.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS50092; TSP1; 3.
DR   PROSITE; PS51234; TSP3; 8.
DR   PROSITE; PS51236; TSP_CTER; 1.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00634};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A3B3ITK0,
KW   ECO:0000213|PeptideAtlas:A0A3B3ITK0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00966518};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19   1177       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017455827.
FT   DOMAIN      318    375       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      554    594       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      653    697       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REPEAT      698    733       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      734    769       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      770    792       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      793    828       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      829    851       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      852    889       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      890    925       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      926    961       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   DOMAIN      965   1177       TSP C-terminal.
FT                                {ECO:0000259|PROSITE:PS51236}.
SQ   SEQUENCE   1177 AA;  130524 MW;  8E19DA8B829D38AD CRC64;
     MVWRLVLLAL WVWPSTQAGH QDKDTTFDLF SISNINRKTI GAKQFRGPDP GVPAYRFVRF
     DYIPPVNADD LSKITKIMRQ KEGFFLTAQL KQDGKSRGTL LALEGPGLSQ RQFEIVSNGP
     ADTLDLTYWI DGTRHVVSLE DVGLADSQWK NVTVQVAGET YSLHVGCDLI DSFALDEPFY
     EHLQAEKSRM YVAKGSARES HFRGLLQNVH LVFENSVEDI LSKKGCQQGQ GAEINAISEN
     TETLRLGPHV TTEYVGPSSE RRPEVCERSC EELGNMVQEL SGLHVLVNQL SENLKRVSND
     NQFLWELIGG PPKTRNMSAC WQDGRFFAEN ETWVVDSCTT CTCKKFKTIC HQITCPPATC
     ASPSFVEGEC CPSCLHSVDG EEGWSPWAEW TQCSVTCGSG TQQRGRSCDV TSNTCLGPSI
     QTRACSLSKC DTRSECRAVR QDGGWSHWSP WSSCSVTCGV GNITRIRLCN SPVPQMGGKN
     CKGSGRETKA CQGAPCPIDG RWSPWSPWSA CTVTCAGGIR ERTRVCNSPE PQYGGKACVG
     DVQERQMCNK RSCPVDGCLS NPCFPGAQCS SFPDGSWSCG SCPVGFLGNG THCEDLDECA
     LVPDICFSTS KVPRCVNTQP GFHCLPCPPR YRGNQPVGVG LEAAKTEKQV CEPENPCKDK
     THNCHKHAEC IYLGHFSDPM YKCECQTGYA GDGLICGEDS DLDGWPNLNL VCATNATYHC
     IKDNCPHLPN SGQEDFDKDG IGDACDDDDD NDGVTDEKDN CQLLFNPRQA DYDKDEVGDR
     CDNCPYVHNP AQIDTDNNGE GDACSVDIDG DDVFNERDNC PYVYNTDQRD TDGDGVGDHC
     DNCPLVHNPD QTDVDNDLVG DQCDNNEDID DDGHQNNQDN CPYISNANQA DHDRDGQGDA
     CDPDDDNDGV PDDRDNCRLV FNPDQEDLDG DGRGDICKDD FDNDNIPDID DVCPENNAIS
     ETDFRNFQMV PLDPKGTTQI DPNWVIRHQG KELVQTANSD PGIAVGFDEF GSVDFSGTFY
     VNTDRDDDYA GFVFGYQSSS RFYVVMWKQV TQTYWEDQPT RAYGYSGVSL KVVNSTTGTG
     EHLRNALWHT GNTPGQVRTL WHDPRNIGWK DYTAYRWHLT HRPKTGYIRV LVHEGKQVMA
     DSGPIYDQTY AGGRLGLFVF SQEMVYFSDL KYECRDI
//