ID   A0A3B3IT43_HUMAN        Unreviewed;      1092 AA.
AC   A0A3B3IT43;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   13-FEB-2019, entry version 3.
DE   SubName: Full=Semaphorin-5B {ECO:0000313|Ensembl:ENSP00000497595};
GN   Name=SEMA5B {ECO:0000313|Ensembl:ENSP00000497595};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000497595, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000497595, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000497595}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   EMBL; AC078794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC083797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC109130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000648990; ENSP00000497595; ENSG00000082684.
DR   HGNC; HGNC:10737; SEMA5B.
DR   OpenTargets; ENSG00000082684; -.
DR   GeneTree; ENSGT00940000156712; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 2.20.100.10; -; 6.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00209; TSP1; 5.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   SUPFAM; SSF82895; SSF82895; 5.
DR   PROSITE; PS51004; SEMA; 1.
DR   PROSITE; PS50092; TSP1; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00656526};
KW   Membrane {ECO:0000256|SAAS:SAAS00106123, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A3B3IT43};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00106123,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00106123,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27   1092       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017269010.
FT   TRANSMEM    975    998       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       45    495       Sema. {ECO:0000259|PROSITE:PS51004}.
SQ   SEQUENCE   1092 AA;  119822 MW;  7D860911CA91EE70 CRC64;
     MVLAGPLAVS LLLPSLTLLV SHLSSSQDVS SEPSSEQQLC ALSKHPTVAF EDLQPWVSNF
     TYPGARDFSQ LALDPSGNQL IVGARNYLFR LSLANVSLLQ ATEWASSEDT RRSCQSKGKT
     EEECQNYVRV LIVAGRKVFM CGTNAFSPMC TSRQVGNLSR TIEKINGVAR CPYDPRHNST
     AVISSQGELY AATVIDFSGR DPAIYRSLGS GPPLRTAQYN SKWLNEPNFV AAYDIGLFAY
     FFLRENAVEH DCGRTVYSRV ARVCKNDVGG RFLLEDTWTT FMKARLNCSR PGEVPFYYNE
     LQSAFHLPEQ DLIYGVFTTN VNSIAASAVC AFNLSAISQA FNGPFRYQEN PRAAWLPIAN
     PIPNFQCGTL PETGPNENLT ERSLQDAQRL FLMSEAVQPV TPEPCVTQDS VRFSHLVVDL
     VQAKDTLYHV LYIGTESGTI LKALSTASRS LHGCYLEELH VLPPGRREPL RSLRILHSAR
     ALFVGLRDGV LRVPLERCAA YRSQGACLGA RDPYCGWDGK QQRCSTLEDS SNMSLWTQNI
     TACPVRNVTR DGGFGPWSPW QPCEHLDGDN SGSCLCRARS CDSPRPRCGG LDCLGPAIHI
     ANCSRNGAWT PWSSWALCST SCGIGFQVRQ RSCSNPAPRH GGRICVGKSR EERFCNENTP
     CPVPIFWASW GSWSKCSSNC GGGMQSRRRA CENGNSCLGC GEFKTCNPEG CPEVRRNTPW
     TPWLPVNVTQ GGARQEQRFR FTCRAPLADP HGLQFGRRRT ETRTCPADGS GSCDTDALVE
     VLLRSGSTSP HTVSGGWAAW GPWSSCSRDC ELGFRVRKRT CTNPEPRNGG LPCVGDAAEY
     QDCNPQACPV RGAWSCWTSW SPCSASCGGG HYQRTRSCTS PAPSPGEDIC LGLHTEEALC
     ATQACPEGWS PWSEWSKCTD DGAQSRSRHC EELLPGSSAC AGNSSQSRPC PYSEIPVILP
     ASSMEEATDC AGFNLIHLVA TGISCFLGSG LLTLAVYLSC QHCQRQSQES TLVHPATPNH
     LHYKGGGTPK NEKYTPMEFK TLNKNNLIPD DRANFYPLQQ TNVYTTTYYP SPLNKHSFRP
     EASPGQRCFP NS
//