ID   A0A3B3ISZ7_HUMAN        Unreviewed;      1028 AA.
AC   A0A3B3ISZ7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   13-FEB-2019, entry version 3.
DE   SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 2 {ECO:0000313|Ensembl:ENSP00000497523};
GN   Name=SCUBE2 {ECO:0000313|Ensembl:ENSP00000497523};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000497523, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000497523, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000497523}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AC079296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005253089.2; XM_005253032.4.
DR   Ensembl; ENST00000649792; ENSP00000497523; ENSG00000175356.
DR   GeneID; 57758; -.
DR   HGNC; HGNC:30425; SCUBE2.
DR   OpenTargets; ENSG00000175356; -.
DR   GeneTree; ENSGT00940000153185; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00041; CUB; 1.
DR   Gene3D; 2.60.120.290; -; 1.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF00431; CUB; 1.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF07699; Ephrin_rec_like; 3.
DR   SMART; SM00042; CUB; 1.
DR   SMART; SM00181; EGF; 10.
DR   SMART; SM00179; EGF_CA; 8.
DR   SMART; SM01411; Ephrin_rec_like; 3.
DR   SUPFAM; SSF49854; SSF49854; 1.
DR   SUPFAM; SSF57184; SSF57184; 4.
DR   PROSITE; PS00010; ASX_HYDROXYL; 4.
DR   PROSITE; PS01180; CUB; 1.
DR   PROSITE; PS01186; EGF_2; 5.
DR   PROSITE; PS50026; EGF_3; 4.
DR   PROSITE; PS01187; EGF_CA; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00909960};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A3B3ISZ7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32   1028       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017451940.
FT   DOMAIN       45     85       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN       86    127       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      364    402       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      403    443       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      838    950       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   COILED      607    627       {ECO:0000256|SAM:Coils}.
FT   DISULFID    368    378       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   1028 AA;  112927 MW;  49791ECA03C2E416 CRC64;
     MGVAGRNRPG AAWAVLLLLL LLPPLLLLAG AVPPGRGRAA GPQEDVDECA QGLDDCHADA
     LCQNTPTSYK CSCKPGYQGE GRQCEDIDEC GNELNGGCVH DCLNIPGNYR CTCFDGFMLA
     HDGHNCLDVD ECLENNGGCQ HTCVNVMGSY ECCCKEGFFL SDNQHTCIHR SEEGLSCMNK
     DHGCSHICKE APRGSVACEC RPGFELAKNQ RDCILTCNHG NGGCQHSCDD TADGPECSCH
     PQYKMHTDGR SCLEREDTVL EVTESNTTSV VDGDKRVKRR LLMETCAVNN GGCDRTCKDT
     STGVHCSCPV GFTLQLDGKT CKDIDECQTR NGGCDHFCKN IVGSFDCGCK KGFKLLTDEK
     SCQDVDECSL DRTCDHSCIN HPGTFACACN RGYTLYGFTH CGDTNECSIN NGGCQQVCVN
     TVGSYECQCH PGYKLHWNKK DCVEVKGLLP TSVSPRVSLH CGKSGGGDGC FLRCHSGIHL
     SSGLQGAYSV TCGSSSPLRN KQQKSNDSAF GDVTTIRTSV TFKLNEGKCS LKNAELFPEG
     LRPALPEKHS SVKESFRYVN LTCSSGKQVP GAPGRPSTPK EMFITVEFEL ETNQKEVTAS
     CDLSCIVKRT EKRLRKAIRT LRKAVHREQF HLQLSGMNLD VAKKPPRTSE RQAESCGVGQ
     GHAENQCVSC RAGTYYDGAR ERCILCPNGT FQNEEGQMTC EPCPRPGNSG ALKTPEAWNM
     SECGGLCQPG EYSADGFAPC QLCALGTFQP EAGRTSCFPC GGGLATKHQG ATSFQDCETR
     VQCSPGHFYN TTTHRCIRCP VGTYQPEFGK NNCVSCPGNT TTDFDGSTNI TQCKNRRCGG
     ELGDFTGYIE SPNYPGNYPA NTECTWTINP PPKRRILIVV PEIFLPIEDD CGDYLVMRKT
     SSSNSVTTYE TCQTYERPIA FTSRSKKLWI QFKSNEGNSA RGFQVPYVTY DEDYQELIED
     IVRDGRLYAS ENHQEILKDK KLIKALFDVL AHPQNYFKYT AQESREMFPR SFIRLLRSKV
     SRFLRPYK
//