ID   A0A3B3ISV0_HUMAN        Unreviewed;       265 AA.
AC   A0A3B3ISV0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   13-FEB-2019, entry version 3.
DE   SubName: Full=Serine protease-like protein 51 {ECO:0000313|Ensembl:ENSP00000497613};
GN   Name=PRSS51 {ECO:0000313|Ensembl:ENSP00000497613};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000497613, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000497613, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000497613}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2018) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
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DR   EMBL; AC104964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000647727; ENSP00000497613; ENSG00000253649.
DR   HGNC; HGNC:37321; PRSS51.
DR   OpenTargets; ENSG00000253649; -.
DR   GeneTree; ENSGT00940000156020; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    265       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017371643.
FT   DOMAIN       23    265       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
SQ   SEQUENCE   265 AA;  30309 MW;  B8DC82CF2B294627 CRC64;
     MFQLLIPLLL ALKGHAQDNP ENVQCGHRPA FPNSSWLPFH ERLQVQNGEC PWQVSIQMSR
     KHLCGGSILH WWWVLTAAHC FRRTLLDMAV VNVTVVMGTR TFSNIHSERK QVQKVIIHKD
     YKPPQLDSDL SLLLLATPVQ FSNFKMPVCL QEEERTWDWC WMAQWVTTNG YDQYDDLNMH
     LEKLRVVQIS RKECAKRINQ LSRNMICAWN EPGTNGIFKG DSGAPLVCAI YGTQRLFQVG
     VFSGGIRSGS RGRPGMFVSV AQFIP
//