ID A0A3B3IRQ7_HUMAN Unreviewed; 279 AA. AC A0A3B3IRQ7; DT 05-DEC-2018, integrated into UniProtKB/TrEMBL. DT 05-DEC-2018, sequence version 1. DT 13-FEB-2019, entry version 3. DE SubName: Full=Alpha-2-macroglobulin receptor-associated protein {ECO:0000313|Ensembl:ENSP00000496947}; GN Name=LRPAP1 {ECO:0000313|Ensembl:ENSP00000496947}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000496947, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000496947, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000496947} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2018) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL590235; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000648517; ENSP00000496947; ENSG00000163956. DR HGNC; HGNC:6701; LRPAP1. DR OpenTargets; ENSG00000163956; -. DR GeneTree; ENSGT00390000004855; -. DR Proteomes; UP000005640; Chromosome 4. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro. DR GO; GO:0005576; C:extracellular region; IEA:GOC. DR GO; GO:0008201; F:heparin binding; IEA:InterPro. DR GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:InterPro. DR GO; GO:0048019; F:receptor antagonist activity; IEA:InterPro. DR CDD; cd14806; RAP_D1; 1. DR CDD; cd14807; RAP_D2; 1. DR Gene3D; 1.20.81.10; -; 2. DR InterPro; IPR038003; A2-macroglobuin_RAP. DR InterPro; IPR010483; Alpha_2_MRAP_C. DR InterPro; IPR009066; MG_RAP_rcpt_1. DR InterPro; IPR038001; RAP_D2. DR InterPro; IPR036744; RAP_sf. DR PANTHER; PTHR16560; PTHR16560; 1. DR Pfam; PF06401; Alpha-2-MRAP_C; 1. DR Pfam; PF06400; Alpha-2-MRAP_N; 1. DR SUPFAM; SSF47045; SSF47045; 2. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A3B3IRQ7, KW ECO:0000213|MaxQB:A0A3B3IRQ7, ECO:0000213|PeptideAtlas:A0A3B3IRQ7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 30 {ECO:0000256|SAM:SignalP}. FT CHAIN 31 279 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5017242736. FT DOMAIN 20 130 Alpha-2-MRAP_N. FT {ECO:0000259|Pfam:PF06400}. FT DOMAIN 146 248 Alpha-2-MRAP_C. FT {ECO:0000259|Pfam:PF06401}. FT COILED 221 241 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 279 AA; 32022 MW; 8180E9DE579B28D1 CRC64; MAPRRVRSFL RGLPALLLLL LFLGPWPAAS HGGKYSREKN QPKPSPKRES GEEFRMEKLN QLWEKAQRLH LPPVRLAELH ADLKIQERDE LAWKKLKLDG LDEDGEKEAR LIRNLNVILA KYGLDGKKDA RQVTSNSLSG TQEDGLDDPR LEKLWHKAKT SGKFSGEELD KLWREFLHHK EKVHEYNVLL ETLSRTEEIH ENVISPSDLS DIKGSVLHSR HTELKEKLRS INQGLDRLRR VSHQGYSTEA GSRSRLGLFG SSQEPECLTF TSTTSCWRP //