ID   A0A2U3TZE7_HUMAN        Unreviewed;       615 AA.
AC   A0A2U3TZE7;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   13-FEB-2019, entry version 5.
DE   SubName: Full=Cochlin {ECO:0000313|Ensembl:ENSP00000216361};
GN   Name=COCH {ECO:0000313|Ensembl:ENSP00000216361};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000216361, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000216361, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000216361}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2018) to UniProtKB.
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DR   EMBL; AL049830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001334649.1; NM_001347720.1.
DR   RefSeq; XP_016876560.1; XM_017021071.1.
DR   UniGene; Hs.21016; -.
DR   Ensembl; ENST00000216361; ENSP00000216361; ENSG00000100473.
DR   GeneID; 1690; -.
DR   CTD; 1690; -.
DR   HGNC; HGNC:2180; COCH.
DR   OpenTargets; ENSG00000100473; -.
DR   GeneTree; ENSGT00940000159386; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   ExpressionAtlas; A0A2U3TZE7; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR   GO; GO:0045089; P:positive regulation of innate immune response; IEA:InterPro.
DR   Gene3D; 2.170.130.20; -; 1.
DR   Gene3D; 3.40.50.410; -; 2.
DR   InterPro; IPR030743; Cochlin.
DR   InterPro; IPR004043; LCCL.
DR   InterPro; IPR036609; LCCL_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR44729; PTHR44729; 1.
DR   Pfam; PF03815; LCCL; 1.
DR   Pfam; PF00092; VWA; 2.
DR   SMART; SM00603; LCCL; 1.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF53300; SSF53300; 2.
DR   SUPFAM; SSF69848; SSF69848; 1.
DR   PROSITE; PS50820; LCCL; 1.
DR   PROSITE; PS50234; VWFA; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A2U3TZE7,
KW   ECO:0000213|MaxQB:A0A2U3TZE7, ECO:0000213|PeptideAtlas:A0A2U3TZE7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    615       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015780790.
FT   DOMAIN       93    186       LCCL. {ECO:0000259|PROSITE:PS50820}.
FT   DOMAIN      230    415       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      432    602       VWFA. {ECO:0000259|PROSITE:PS50234}.
SQ   SEQUENCE   615 AA;  66300 MW;  C247A1BE46E30DBA CRC64;
     MSAAWIPALG LGVCLLLLPG PAGSEGAGEW GSWGASRRSQ GLSTSGYKRD SDPAPWASAL
     PPEEEGAKVE PPRGAPALTP AADLLLLTCF SHAPIAITCF TRGLDIRKEK ADVLCPGGCP
     LEEFSVYGNI VYASVSSICG AAVHRGVISN SGGPVRVYSL PGRENYSSVD ANGIQSQMLS
     RWSASFTVTK GKSSTQEATG QAVSTAHPPT GKRLKKTPEK KTGNKDCKAD IAFLIDGSFN
     IGQRRFNLQK NFVGKVALML GIGTEGPHVG LVQASEHPKI EFYLKNFTSA KDVLFAIKEV
     GFRGGNSNTG KALKHTAQKF FTVDAGVRKG IPKVVVVFID GWPSDDIEEA GIVAREFGVN
     VFIVSVAKPI PEELGMVQDV TFVDKAVCRN NGFFSYHMPN WFGTTKYVKP LVQKLCTHEQ
     MMCSKTCYNS VNIAFLIDGS SSVGDSNFRL MLEFVSNIAK TFEISDIGAK IAAVQFTYDQ
     RTEFSFTDYS TKENVLAVIR NIRYMSGGTA TGDAISFTVR NVFGPIRESP NKNFLVIVTD
     GQSYDDVQGP AAAAHDAGIT IFSVGVAWAP LDDLKDMASK PKESHAFFTR EFTGLEPIVS
     DVIRGICRDF LESQQ
//