ID   A0A2R8YGW0_HUMAN        Unreviewed;       590 AA.
AC   A0A2R8YGW0;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
DE   Flags: Fragment;
GN   Name=CLCN5 {ECO:0000313|Ensembl:ENSP00000496353};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000496353, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000496353, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [3] {ECO:0000313|Ensembl:ENSP00000496353}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361221};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361221}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       {ECO:0000256|RuleBase:RU361221, ECO:0000256|SAAS:SAAS00594782}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR   EMBL; AC231645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC236430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000642383; ENSP00000496353; ENSG00000171365.
DR   HGNC; HGNC:2023; CLCN5.
DR   OpenTargets; ENSG00000171365; -.
DR   GeneTree; ENSGT00940000153763; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   ExpressionAtlas; A0A2R8YGW0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3080.10; -; 2.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00654; Voltage_CLC; 2.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF81340; SSF81340; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   1: Evidence at protein level;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Chloride {ECO:0000256|RuleBase:RU361221,
KW   ECO:0000256|SAAS:SAAS00523295};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion transport {ECO:0000256|RuleBase:RU361221,
KW   ECO:0000256|SAAS:SAAS00523481};
KW   Membrane {ECO:0000256|RuleBase:RU361221,
KW   ECO:0000256|SAAS:SAAS00523314};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A2R8YGW0,
KW   ECO:0000213|PeptideAtlas:A0A2R8YGW0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|RuleBase:RU361221,
KW   ECO:0000256|SAAS:SAAS00523314};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361221,
KW   ECO:0000256|SAAS:SAAS00523314};
KW   Transport {ECO:0000256|RuleBase:RU361221,
KW   ECO:0000256|SAAS:SAAS00523481}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    590       Chloride channel protein.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015308446.
FT   TRANSMEM     62     86       Helical. {ECO:0000256|RuleBase:RU361221}.
FT   TRANSMEM    136    155       Helical. {ECO:0000256|RuleBase:RU361221}.
FT   TRANSMEM    175    192       Helical. {ECO:0000256|RuleBase:RU361221}.
FT   TRANSMEM    251    272       Helical. {ECO:0000256|RuleBase:RU361221}.
FT   DOMAIN      430    494       CBS. {ECO:0000259|PROSITE:PS51371}.
FT   DOMAIN      526    586       CBS. {ECO:0000259|PROSITE:PS51371}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000496353}.
SQ   SEQUENCE   590 AA;  65359 MW;  E038DBFD1AF5BE0F CRC64;
     IIRGYLGKWT LVIKTITLVL AVSSGLSLGK EGPLVHVACC CGNILCHCFN KYRKNEAKRR
     EVLSAAAAAG VSVAFGAPIG GVLFSLEEVS YYFPLKTLWR SFFAALVAAF TLRSINPFGN
     SRLVLFYVEF HTPWHLFELV PFILLGIFGG LWGALFIRTN IAWCRKRKTT QLGKYPVIEV
     LVVTAITAIL AFPNEYTRMS TSELISELFN DCGLLDSSKL CDYENRFNTS KGGELPDRPA
     GVGVYSAMWQ LALTLILKIV ITIFTFGMKA QFLPPVLCWS GEFRLLPDGP RIRIPSGLFI
     PSMAVGAIAG RLLGVGMEQL AYYHQEWTVF NSWCSQGADC ITPGLYAMVG AAACLGGVTR
     MTVSLVVIMF ELTGGLEYIV PLMAAAMTSK WVADALGREG IYDAHIRLNG YPFLEAKEEF
     AHKTLAMDVM KPRRNDPLLT VLTQDSMTVE DVETIISETT YSGFPVVVSR ESQRLVGFVL
     RRDLIISIEN ARKKQDGVVS TSIIYFTEHS PPLPPYTPPT LKLRNILDLS PFTVTDLTPM
     EIVVDIFRKL GLRQCLVTHN GRLLGIITKK DVLKHIAQMA NQDPDSILFN
//