ID A0A2R8YGD1_HUMAN Unreviewed; 470 AA. AC A0A2R8YGD1; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 13-FEB-2019, entry version 4. DE SubName: Full=Tripeptidyl-peptidase 1 {ECO:0000313|Ensembl:ENSP00000495895}; GN Name=TPP1 {ECO:0000313|Ensembl:ENSP00000495895}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000495895, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000495895, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000495895} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01032}; CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE- CC ProRule:PRU01032}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC091564; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000644810; ENSP00000495895; ENSG00000166340. DR HGNC; HGNC:2073; TPP1. DR OpenTargets; ENSG00000166340; -. DR GeneTree; ENSGT00390000008684; -. DR Proteomes; UP000005640; Chromosome 11. DR ExpressionAtlas; A0A2R8YGD1; baseline and differential. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule. DR CDD; cd04056; Peptidases_S53; 1. DR Gene3D; 3.40.50.200; -; 1. DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf. DR InterPro; IPR015366; S53_propep. DR InterPro; IPR030400; Sedolisin_dom. DR Pfam; PF09286; Pro-kuma_activ; 1. DR SMART; SM00944; Pro-kuma_activ; 1. DR SUPFAM; SSF52743; SSF52743; 1. DR PROSITE; PS51695; SEDOLISIN; 1. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|PROSITE-ProRule:PRU01032}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032}; KW Protease {ECO:0000256|PROSITE-ProRule:PRU01032}; KW Proteomics identification {ECO:0000213|EPD:A0A2R8YGD1, KW ECO:0000213|MaxQB:A0A2R8YGD1, ECO:0000213|PeptideAtlas:A0A2R8YGD1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 470 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015333583. FT DOMAIN 106 470 Peptidase S53. FT {ECO:0000259|PROSITE:PS51695}. FT ACT_SITE 179 179 Charge relay system. FT {ECO:0000256|PROSITE-ProRule:PRU01032}. FT ACT_SITE 183 183 Charge relay system. FT {ECO:0000256|PROSITE-ProRule:PRU01032}. FT ACT_SITE 382 382 Charge relay system. FT {ECO:0000256|PROSITE-ProRule:PRU01032}. FT METAL 424 424 Calcium. {ECO:0000256|PROSITE- FT ProRule:PRU01032}. FT METAL 425 425 Calcium; via carbonyl oxygen. FT {ECO:0000256|PROSITE-ProRule:PRU01032}. FT METAL 448 448 Calcium; via carbonyl oxygen. FT {ECO:0000256|PROSITE-ProRule:PRU01032}. FT METAL 450 450 Calcium. {ECO:0000256|PROSITE- FT ProRule:PRU01032}. SQ SEQUENCE 470 AA; 50890 MW; 69EEF9890A456887 CRC64; MGLQACLLGL FALILSGKCS YSPEPDQRRT LPPGWVSLGR ADPEEELSLT FALRQQNVER LSELVQAVSD PSSPQYVGGL HRFPPTSSLR QRPEPQVTGT VGLHLGVTPS VIRKRYNLTS QDVGSGTSNN SQACAQFLEQ YFHDSDLAQF MRLFGGNFAH QASVARVVGQ QGRGRAGIEA SLDVQYLMSA GANISTWVYS SPGRHEGQEP FLQWLMLLSN ESALPHVHTV SYGDDEDSLS SAYIQRVNTE LMKAAARGLT LLFASGDSGA GCWSVSGRHQ FRPTFPASSP YVTTVGGTSF QEPFLITNEI VDYISGGGFS NVFPRPSYQE EAVTKFLSSS PHLPPSSYFN ASGRAYPDVA ALSDGYWVVS NRVPIPWVSG TSASTPVFGG ILSLINEHRI LSGRPPLGFL NPRLYQQHGA GLFDVTRGCH ESCLDEEVEG QGFCSGPGWD PVTGWGTPNF PALLKTLLNP //