ID   A0A2R8YF04_HUMAN        Unreviewed;      2308 AA.
AC   A0A2R8YF04;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 5.
DE   SubName: Full=Otogelin-like protein {ECO:0000313|Ensembl:ENSP00000496036};
GN   Name=OTOGL {ECO:0000313|Ensembl:ENSP00000496036};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000496036, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000496036, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000496036}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00567783}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR   EMBL; AC078817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC083812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000646859; ENSP00000496036; ENSG00000165899.
DR   HGNC; HGNC:26901; OTOGL.
DR   OpenTargets; ENSG00000165899; -.
DR   GeneTree; ENSGT00940000160698; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   ExpressionAtlas; A0A2R8YF04; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR   GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR007934; AbfB_ABD.
DR   InterPro; IPR036195; AbfB_ABD_sf.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR030110; Otogl.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339:SF225; PTHR11339:SF225; 3.
DR   Pfam; PF05270; AbfB; 1.
DR   Pfam; PF08742; C8; 4.
DR   Pfam; PF01826; TIL; 1.
DR   Pfam; PF00094; VWD; 4.
DR   SMART; SM00832; C8; 4.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00215; VWC_out; 2.
DR   SMART; SM00216; VWD; 4.
DR   SUPFAM; SSF110221; SSF110221; 1.
DR   SUPFAM; SSF57567; SSF57567; 4.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS51233; VWFD; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00039,
KW   ECO:0000256|SAAS:SAAS00509702};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A2R8YF04};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00509699};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32   2308       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015331691.
FT   DOMAIN      122    335       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      482    692       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      947    976       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      982   1105       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     1490   1710       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     2216   2308       CTCK. {ECO:0000259|PROSITE:PS01225}.
FT   DISULFID   2237   2286       {ECO:0000256|PROSITE-ProRule:PRU00039}.
SQ   SEQUENCE   2308 AA;  259677 MW;  B003B25C1F0C0535 CRC64;
     MNIVRKLNLM IPWSIFLLHV LLFSLQEYIC ASSILMGTSK NGFNENRQKR ALLAAQFEAT
     SPRYFFHDAI NWGESKIKGS CPYECLNGAF CSKTGTCDCQ IFQALGTRCQ IIPNMGNGRD
     GICKTWGQYH FETFDGIYYY FPGNCSYIFA KDCGDLEPRY TVWVHNSPKC LGSVYSCYRS
     ISLFFSNQEE IRIYGHEIKK NGISLTLPQT IGQIFIEKLA DYILVKTTFG FSLAWDGISG
     IYLKLSEDHK GKSCGLCGNY NDIQSDDFII LQEDYTEDIA MFANSWSVQT PDDTKCVLTP
     SDFPNPCSSG MPAFEAIFFK CQILLQFPFL SCHEYIDPYL YIASCVNDLC KTDDDETYCR
     AATEYARACS HAGYPIQDWR DDFPACTDKC DDSFVHRDCI SCCPPTCTFE KQCLGSNLHC
     LDGCYCPDGL VMDNGTCISL ENCPCGFHGL AYSVGSKIEQ ECTECVCVGG VWNCTEQDCP
     VQCSVVGDSH FTTFDGRHYS FIGMCQYILV KGTGKDKFTI TLQKAPCEQN LGLVCLQSIT
     LILEDDFNKQ VTLGRGGQIL TSPNQGFNLN GIVEIQTLSS LFILLKTTFG LKILFAIDGE
     RIYIQLTSAW KRRTLGLCGT FNGNIRDDFL SPSGMIEGTP QLHANAWRVS STCFAPVHVP
     VVDPCNINQQ NIGYAAHCDV IHQELFAPCH IYISPGLYYQ LCRHDACKCG SSCLCNALAH
     YAYLCGQHGV PIDFRTQISF CAVVCQKGML YHHCSSFCLH SCISLSSPEQ CSDDCAEGCN
     CPEGKFYEDT LNFCVPIFHC RCHYRGSVYQ PGELIPTPSG LCQCSNGTVK CDELATPSAV
     HICPEGKEYF DCRFPDPELP AGGVNCETTC ANLAMNFTCT PSSPCISGCV CAPGMAEHRG
     KCYVPESCPC IWKDWEYLSG EVIATPCYTC VCRRGMFNCT YYPCPAVCTI YGDRHYYSFD
     GLEYDYISDC QVFLIKKQSG FFLENKSTYQ LWKAGYYIVV YFPEKDITIL WDRKTTIHIK
     VGPQWKNKLS GLCGNFDKCT SNDMTTSNNL EVRNARVFGD SWALGQCESP DETIKPCEAH
     QNKFPYAKKE CSILYSDIFA SCRNVIDVTS FAKNCHEDTC NCNLGGDCEC LCTSIAAYAY
     KCCQEGISIH WRSSTVCSLD CEYYNEGLGE GPYMLASYGQ SGLVLGANMT SRSVFCLPRS
     SVHTSLFFYF MITPGLFKEK VSSLALVSLE SAERPNYFLY VHDNDTLSLE LWEANSAFHR
     RATFFHHQGL WIPGYSAFEL YSKKGFFIIF TDSSVKASKY DDSEEFKHSS SFSIEEIQAA
     VPYRKMCEWR YEPCATPCFK TCSDPEALAC KFLPPVEGCL PYCPKNMILD EVTLKCVYPR
     DCIPVIPTEP TLMPPAKPTV PMFTVWEMIT PSDITVFDML TPTTGLECEP QKFDPVYDCS
     QYICLNMEWQ LYNWSLNCPK DVEMPDCGFR GRPVQVNSDI CCPEWECPCR CSMLSELSII
     TFDGNNAALY SMASYILVRI PGEIIVAHIE KCSMNQNGNS LKKLAPSGRI SGLCFKKLNV
     TTPIHKIIVN RLARKVEVDS IVVPLPFSSQ ELSIEDSGSM YVITTPAGLI IKWSHLTGII
     DIHFGFRFNL SSYTEGLCGI CNEDPDDDLR MQNGTIITNM EDIGLFIESW EIEKSFEVTM
     RRPVRNCTEH DCSQCIDLLN RRIFIPCHDK VSPEDFCEKM WINYTYFWNY ECDALSAYVA
     LCNKFDICIQ WRTPDYCSLS CPEGKEYQPC VRPCEARTCL NQWFYGHTSC LNLREDCVCK
     VGTILHRPHS AQCIPEKECA CTDSEDQPRT AGEIWNGGID ECTLYKCLEN GSIIPIEPDC
     DEEPTPVCER EAEVVMGIID KWTCCSKEVC GCDTTLCETS IPTCTNSQKL IVGHSPLSCC
     PQYKCECDPL KCPSISTPEC REDQFMIQVR QEEPCCFSPF CVCESCTKPV PLCHDGEFLT
     VDLNSTHFCC PQYYCVCEPN LCPMPLLNCA EDMNLVKENV SGQCCPTWHC ECNCENLIMP
     TCEVGEFTAI DHNFQSDCGC IQYLCEKDDV CVFQEVSVLN PGQSMIKYLE EDFCYAIECL
     EEKDNHTGFH TLNFTLVNCS KKCDVHQVYT PSPSDYGCCG TCKNVSCKFH MENGTSVVYA
     VGSTWHYNCT TYECVKTDEG AIILNYTMVC PPFNETECKM NEGIVKLYNE GCCKICKREE
     RICQKVIIKS VIRKQDCMSQ SPINVASCDG KCPSATIYNI NIESHLRFCK CCRENGVRNL
     SVPLYCSGNG TEIMYTLQEP IDCTCQWN
//