ID   A0A2R8YEI1_HUMAN        Unreviewed;       205 AA.
AC   A0A2R8YEI1;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 5.
DE   SubName: Full=Hepatocyte growth factor {ECO:0000313|Ensembl:ENSP00000494355};
GN   Name=HGF {ECO:0000313|Ensembl:ENSP00000494355};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000494355, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000494355, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000494355}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR   EMBL; AC004960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000465234; ENSP00000494355; ENSG00000019991.
DR   HGNC; HGNC:4893; HGF.
DR   OpenTargets; ENSG00000019991; -.
DR   GeneTree; ENSGT00940000156019; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   ExpressionAtlas; A0A2R8YEI1; baseline and differential.
DR   CDD; cd00108; KR; 1.
DR   Gene3D; 2.40.20.10; -; 1.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR018056; Kringle_CS.
DR   InterPro; IPR038178; Kringle_sf.
DR   InterPro; IPR003609; Pan_app.
DR   Pfam; PF00051; Kringle; 1.
DR   Pfam; PF00024; PAN_1; 1.
DR   SMART; SM00130; KR; 1.
DR   SMART; SM00473; PAN_AP; 1.
DR   SUPFAM; SSF57440; SSF57440; 1.
DR   PROSITE; PS00021; KRINGLE_1; 1.
DR   PROSITE; PS50070; KRINGLE_2; 1.
DR   PROSITE; PS50948; PAN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00045912};
KW   Kringle {ECO:0000256|PROSITE-ProRule:PRU00121,
KW   ECO:0000256|SAAS:SAAS00045973};
KW   Proteomics identification {ECO:0000213|EPD:A0A2R8YEI1,
KW   ECO:0000213|MaxQB:A0A2R8YEI1, ECO:0000213|PeptideAtlas:A0A2R8YEI1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    205       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015333552.
FT   DOMAIN       37    123       Apple. {ECO:0000259|PROSITE:PS50948}.
FT   DOMAIN      127    201       Kringle. {ECO:0000259|PROSITE:PS50070}.
SQ   SEQUENCE   205 AA;  23584 MW;  093B0F9B93894184 CRC64;
     MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK
     TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE
     NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SYRGKDLQEN YCRNPRGEEG
     GPWCFTSNPE VRYEVCDIPQ CSEGK
//