ID   A0A2R8YEC9_HUMAN        Unreviewed;       925 AA.
AC   A0A2R8YEC9;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 4.
DE   SubName: Full=Beta-mannosidase {ECO:0000313|Ensembl:ENSP00000495483};
GN   Name=MANBA {ECO:0000313|Ensembl:ENSP00000495483};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000495483, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000495483, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000495483}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
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DR   EMBL; AC018797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF213884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF454940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000642252; ENSP00000495483; ENSG00000109323.
DR   HGNC; HGNC:6831; MANBA.
DR   OpenTargets; ENSG00000109323; -.
DR   GeneTree; ENSGT00390000001670; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   ExpressionAtlas; A0A2R8YEC9; baseline and differential.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR006103; Glyco_hydro_2_cat.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF02836; Glyco_hydro_2_C; 1.
DR   SUPFAM; SSF49303; SSF49303; 3.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A2R8YEC9,
KW   ECO:0000213|MaxQB:A0A2R8YEC9, ECO:0000213|PeptideAtlas:A0A2R8YEC9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    925       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015339347.
FT   DOMAIN      442    607       Glyco_hydro_2_C.
FT                                {ECO:0000259|Pfam:PF02836}.
SQ   SEQUENCE   925 AA;  106051 MW;  64084AC802C40EBD CRC64;
     MRLHLLLLLA LCGAGTTAAE LSYSLRGNWS ICNGNGSLEL PGAVPGCVHS ALFQQGLIQD
     SYYRFNDLNY RWVSLDNWTY SKEFKIPFEI SKWQKVNLIL EGVDTVSKIL FNEVTIGETD
     NMFNRYSFDI TNVVRDVNSI ELRFQSAVLY AAQQSKAHTR YQVPPDCPPL VQKGECHVNF
     VRKEQCSFSW DWGPSFPTQG IWKDVRIEAY NICHLNYFTF SPIYDKSAQE WNLEIESTFD
     VVSSKPVGGQ VIVAIPKLQT QQTYSIELQP GKRIVELFVN ISKNITVETW WPHGHGNQTG
     YNMTVLFELD GGLNIEKSAK VYFRTVELIE EPIKGSPGLS FYFKINGFPI FLKGSNWIPA
     DSFQDRVTSE LFHKKMKFFS RHSHGIIGSI FFLFKCSSPL PAGAGLAVVL QPNWANWLRL
     LLQSVVDANM NTLRVWGGGI YEQDEFYELC DELGIMVWQD FMFACALYPT DQGFLDSVTA
     EVAYQIKRLK SHPSIIIWSG NNENEEALMM NWYHISFTDR PIYIKDYVTL YVKNIRELVL
     AGDKSRPFIT SSPTNGAETV AEAWVSQNPN SNYFGDVHFY DYISDCWNWK VFPKARFASE
     YGYQSWPSFS TLEKVSSTED WSFNSKFSLH RQHHEGGNKQ MLYQAGLHFK LPQSTDPLRT
     FKDTIYLTQV MQAQCVKTET EFYRRSRSEI VDQQGHTMGA LYWQLNDIWQ APSWASLEYG
     GKWKMLHYFA QNFFAPLLPV GFENENTFYI YGVSDLHSDY SMTLSVRVHT WSSLEPVCSR
     VTERFVMKGG EAVCLYEEPV SELLRRCGNC TRESCVVSFY LSADHELLSP TNYHFLSSPK
     EAVGLCKAQI TAIISQQGDI FVFDLETSAV APFVWLDVGS IPGRFSDNGF LMTEKTRTIL
     FYPWEPTSKN ELEQSFHVTS LTDIY
//