ID   A0A2R8YE64_HUMAN        Unreviewed;       162 AA.
AC   A0A2R8YE64;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 4.
DE   SubName: Full=Tripeptidyl-peptidase 1 {ECO:0000313|Ensembl:ENSP00000494085};
GN   Name=TPP1 {ECO:0000313|Ensembl:ENSP00000494085};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000494085, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000494085, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000494085}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
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DR   EMBL; AC091564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000644683; ENSP00000494085; ENSG00000166340.
DR   HGNC; HGNC:2073; TPP1.
DR   OpenTargets; ENSG00000166340; -.
DR   GeneTree; ENSGT00390000008684; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   ExpressionAtlas; A0A2R8YE64; baseline and differential.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   InterPro; IPR015366; S53_propep.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A2R8YE64,
KW   ECO:0000213|MaxQB:A0A2R8YE64, ECO:0000213|PeptideAtlas:A0A2R8YE64};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    162       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015312235.
FT   DOMAIN       32    162       Pro-kuma_activ.
FT                                {ECO:0000259|SMART:SM00944}.
SQ   SEQUENCE   162 AA;  17971 MW;  2BB8821735E9CB1D CRC64;
     MGLQACLLGL FALILSGKCS YSPEPDQRRT LPPGWVSLGR ADPEEELSLT FALRQQNVER
     LSELVQAVSD PSSPQYGKYL TLENVADLVR PSPLTLHTVQ KWLLAAGAQK CHSVITQDFL
     TCWLSIRQAE LLLPGAEFHH YVGGPTETHV WGDCTVFPQH HP
//