ID   A0A2R8YDL0_HUMAN        Unreviewed;      2150 AA.
AC   A0A2R8YDL0;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 5.
DE   SubName: Full=Alpha-tectorin {ECO:0000313|Ensembl:ENSP00000493855};
GN   Name=TECTA {ECO:0000313|Ensembl:ENSP00000493855};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000493855, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000493855, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000493855}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00547744}.
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DR   EMBL; AP000646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000642222; ENSP00000493855; ENSG00000109927.
DR   HGNC; HGNC:11720; TECTA.
DR   OpenTargets; ENSG00000109927; -.
DR   GeneTree; ENSGT00940000154874; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   ExpressionAtlas; A0A2R8YDL0; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR003886; NIDO_dom.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR033026; TECTA.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR025615; TILa_dom.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   InterPro; IPR001507; ZP_dom.
DR   InterPro; IPR017977; ZP_dom_CS.
DR   PANTHER; PTHR11339:SF235; PTHR11339:SF235; 1.
DR   Pfam; PF08742; C8; 4.
DR   Pfam; PF06119; NIDO; 1.
DR   Pfam; PF01826; TIL; 3.
DR   Pfam; PF12714; TILa; 2.
DR   Pfam; PF00094; VWD; 4.
DR   Pfam; PF00100; Zona_pellucida; 1.
DR   SMART; SM00832; C8; 4.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00539; NIDO; 1.
DR   SMART; SM00215; VWC_out; 3.
DR   SMART; SM00216; VWD; 4.
DR   SMART; SM00241; ZP; 1.
DR   SUPFAM; SSF57567; SSF57567; 3.
DR   PROSITE; PS51220; NIDO; 1.
DR   PROSITE; PS51233; VWFD; 4.
DR   PROSITE; PS00682; ZP_1; 1.
DR   PROSITE; PS51034; ZP_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00500730};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A2R8YDL0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00500734};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23   2150       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015317097.
FT   DOMAIN       98    252       NIDO. {ECO:0000259|PROSITE:PS51220}.
FT   DOMAIN      321    540       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      712    929       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     1099   1317       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     1486   1702       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     1800   2054       ZP. {ECO:0000259|PROSITE:PS51034}.
SQ   SEQUENCE   2150 AA;  238993 MW;  1452D309BAD76335 CRC64;
     MNYSSFLRIW VSFIFALVQH QAQPRELMYP FWQNDTKTPK VDDGSSSEIK LAIPVFFFGV
     PYRTVYVNNN GVVSFNVLVS QFTPESFPLT DGRAFVAPFW ADVHNGIRGE IYYRETMEPA
     ILKRATKDIR KYFKDMATFS ATWVFIVTWE EVTFYGGSST TPVNTFQAVL VSDGSYTFTL
     FNYYEINWTT GTASGGDPLT GLGGVMAQAG FNGGNLTNFF SLPGSRTPEI VNIQETTNVN
     VPGRWAFKVD GKEIDPANGC TSRGQFLRRG EVFWDDLNCT VKCRCLDFNN EIYCQEASCS
     PYEVCEPKGK FFYCSAVETS TCVVFGEPHY HTFDGFLFHF QGSCAYLLAR QCLQTSSLPF
     FSVEAKNEHR RGSAVSWVKE LSVEVNGYKI LIPKGSYGRV KVNDLVTSLP VTLDLGTVKI
     YQSGISTAVE TDFGLLVTFD GQHYASISVP GSYINSTCGL CGNYNKNPLD DFLRPDGRPA
     MSVLDLGESW RVYHADWKCD SGCVDNCTQC DAATEALYFG SDYCGFLNKT DGPLWECGTV
     VDPTAFVHSC VYDLCSVRDN GTLLCQAIQA YALVCQALGI PIGDWRTQTG CVSTVQCPSF
     SHYSVCTSSC PDTCSDLTAS RNCATPCTEG CECNQGFVLS TSQCVPLHKC GCDFDGHYYT
     MGEFFWATAN CTVQCLCEEG GDVYCFNKTC GSGEVCAVED GYQGCFPKRE TVCLLSQNQV
     LHTFDGASYA FPSEFSYTLL KTCPERPEYL EIDINKKKPD AGPAWLRGLR ILVADQEVKI
     GGIGASEVKL NGQEVELPFF HPSGKLEIYR NKNSTTVESK GVVTVQYSDI GLLYIRLSTT
     YFNCTGGLCG FYNANASDEF CLPNGKCTDN LAVFLESWTT FEEICNGECG DLLKACNNDS
     ELLKFYRSRS RCGIINDPSN SSFLECHGVV NVTAYYRTCL FRLCQSGGNE SELCDSVARY
     ASACKNADVE VGPWRTYDFC PLECPENSHF EECITCTETC ETLTLGPICV DSCSEGCQCD
     EGYALLGSQC VTRSECGCNF EGHQLATNET FWVDLDCQIF CYCSGTDNRV HCETIPCKDD
     EYCMEEGGLY YCQARTDASC IVSGYGHYLT FDGFPFDFQT SCPLILCTTG SRPSSDSFPK
     FVVTAKNEDR DPSLALWVKQ VDVTVFGYSI VIHRAYKHTV LVNSERLYLP LKLGQGKINI
     FSFGFHVVVE TDFGLKVVYD WKTFLSITVP RSMQNSTYGL CGRYNGNPDD DLEMPMGLLA
     SSVNEFGQSW VKRDTFCQVG CGDRCPSCAK VEGFSKVQQL CSLIPNQNAA FSKCHSKVNP
     TFFYKNCLFD SCIDGGAVQT ACSWLQNYAS TCQTQGITVT GWRNYTSCTV TCPPNSHYES
     CVSVCQPRCA AIRLKSDCSH YCVEGCHCDA GYVLNGKSCI LPHSCGCYSD GKYYEPKQLF
     WNSDCTRRCR CFRRNVIQCD PRQCKSDEEC ALRNGVRGCF STKTSYCLAA GGGVFRTFDG
     AFLRFPANCA FVLSTICQKL PDISFQLIIN FDKWSAPNLT IISPVYFYIN EEQILINDRN
     TVKVNGTQVN VPFITGLATK IYSSEGFLVI DTSPDIQIYY NGFNVIKISI SERLQNKVCG
     LCGNFNGDLT DDYVTLRGKP VVSSVVLAQS WKTNGMQKSC NELQFSQYAA MCDNVHIQKM
     QGDGYCLKLT DMKGFFQPCY GLLDPLPFYE SCYLDGCYSH KKFQLCGSLA AYGEACRSFG
     ILSTEWIEKE NCSGVVEDPC VGADCPNRTC ELGNGRELCG CIEPPPYGNN SHDIIDAEVT
     CKAAQMEVSI SKCKLFQLGF EREGVRINDR QCTGIEGEDF ISFQINNTKG NCGNIVQSNG
     THIMYKNTLW IESANNTGNI ITRDRTINVE FSCAYELDIK ISLDSVVKPM LSVINLTVPT
     QEGSFITKMA LYKNASYKHP YRQGEVVLTT RDVLYVGVFV VGADATHLIL TLNKCYATPT
     RDSNDKLRYF IIEGGCQNLK DNTIGIEENA VSLTCRFHVT VFKFIGDYDE VHLHCAVSLC
     DSEKYSCKIT CPHNSRIATD YTKEPKEQII SVGPIRRKRL DWCEDNGGCE QICTSRVDGP
     LCSCVTGTLQ EDGKSCRASN SSMELQVWTL LLIMIQISLW HFVYKSGTTS
//