ID   A0A2R8Y870_HUMAN        Unreviewed;       744 AA.
AC   A0A2R8Y870;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 5.
DE   RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
DE   Flags: Fragment;
GN   Name=KIFC2 {ECO:0000313|Ensembl:ENSP00000496539};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000496539, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000496539, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000496539}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00283, ECO:0000256|RuleBase:RU000394,
CC       ECO:0000256|SAAS:SAAS00583243}.
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DR   EMBL; AC084125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000642354; ENSP00000496539; ENSG00000167702.
DR   HGNC; HGNC:29530; KIFC2.
DR   OpenTargets; ENSG00000167702; -.
DR   GeneTree; ENSGT00940000154022; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   ExpressionAtlas; A0A2R8Y870; baseline and differential.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|RuleBase:RU000394, ECO:0000256|SAAS:SAAS00427985};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Microtubule {ECO:0000256|RuleBase:RU000394};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|RuleBase:RU000394};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|RuleBase:RU000394, ECO:0000256|SAAS:SAAS00427985};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A2R8Y870};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    744       Kinesin-like protein.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015363503.
FT   DOMAIN      392    713       Kinesin motor.
FT                                {ECO:0000259|PROSITE:PS50067}.
FT   NP_BIND     467    474       ATP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00283}.
FT   COILED      199    226       {ECO:0000256|SAM:Coils}.
FT   COILED      229    249       {ECO:0000256|SAM:Coils}.
FT   COILED      276    303       {ECO:0000256|SAM:Coils}.
FT   NON_TER     744    744       {ECO:0000313|Ensembl:ENSP00000496539}.
SQ   SEQUENCE   744 AA;  80250 MW;  1DE68ED75C1DB39D CRC64;
     MYAFYSLLIY IFYSLFRRDG GAAAAAEPGD PAQRARKPRG RRRPDLPAPE LWTELTGLAA
     SSEPEDGSEG AAEGRAAAVS LEEALLRLAE FLSVQLGAEE SCGGPADLGQ SGEVPSLLTV
     TSQLLALLAW LRSPRGRQAL LQGTQPAPRV RPPSPDGSTS QEESPSHFTA VPGEPLGDET
     QGQQPLQLEE DQRAWQRLEQ LILGQLEELK QQLEQQEEEL GRLRLGVGAT DSEKRVQHLT
     LENEALKQSL SLMRDLLLHW GPGPPIRAPQ EEAEALLELQ GRLQEAQDTT EALRAQLQQE
     TEQNCRRELQ QMHGQLAGLR ARMASLRQGC GDLRGLVSTF TQSCQGSLSE ARGQVSWALG
     ALSSGGPGTQ LPEGQQGPPA GCPGRLPELK GNIRVLCRLR PGTSSSLVSV EPGPGGTVTT
     CYRGRHRRFR LDWVFPPDAS QEEVFRELEP AVLSCLRGYS VCIFTYGQTG TGKTYSMEGP
     PEDPGIVPRA LQSLFREMGA GRQHRVTLSM VEIYNEAVRD LLAPGPPERL AVRQGPEGQG
     GIQVAGLTHW DVPNLETLHQ MLKLGRSNRA TAATAMNQRS SRSHALVTLT LRAASPPRAP
     GTAGTLHLVD LAGSERARKA GAAGPPRGDP DGARRLREAQ TINRSLLALG GVMAALRAHR
     PHVPFRDSQL TRLLQPALGP GTTAVLLLQI STRPEDLGET VCSLKFADRV GQVELGPARR
     RRVPRSSGTP SSLSTDTPLT GTPC
//