ID A0A2R8Y780_HUMAN Unreviewed; 889 AA. AC A0A2R8Y780; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 13-FEB-2019, entry version 5. DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722}; GN Name=SLC9A3 {ECO:0000313|Ensembl:ENSP00000495903}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000495903, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000495903, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000495903} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 CC (CPA1) transporter (TC 2.A.36) family. CC {ECO:0000256|RuleBase:RU003722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010442; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC106772; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF457845; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000644203; ENSP00000495903; ENSG00000066230. DR HGNC; HGNC:11073; SLC9A3. DR OpenTargets; ENSG00000066230; -. DR GeneTree; ENSGT00940000158616; -. DR Proteomes; UP000005640; Chromosome 5. DR ExpressionAtlas; A0A2R8Y780; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro. DR GO; GO:0006885; P:regulation of pH; IEA:InterPro. DR InterPro; IPR006153; Cation/H_exchanger. DR InterPro; IPR018422; Cation/H_exchanger_CPA1. DR InterPro; IPR018410; Na/H_exchanger_3/5. DR InterPro; IPR004709; NaH_exchanger. DR PANTHER; PTHR10110; PTHR10110; 1. DR Pfam; PF00999; Na_H_Exchanger; 1. DR PRINTS; PR01084; NAHEXCHNGR. DR PRINTS; PR01087; NAHEXCHNGR3. DR TIGRFAMs; TIGR00840; b_cpa1; 1. PE 1: Evidence at protein level; KW Antiport {ECO:0000256|RuleBase:RU003722, KW ECO:0000256|SAAS:SAAS00029193}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Ion transport {ECO:0000256|RuleBase:RU003722}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A2R8Y780}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Sodium {ECO:0000256|RuleBase:RU003722}; KW Sodium transport {ECO:0000256|RuleBase:RU003722}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU003722, KW ECO:0000256|SAAS:SAAS00029193}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 889 Sodium/hydrogen exchanger. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015331671. FT TRANSMEM 56 74 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 86 102 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 114 131 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 143 166 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 178 200 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 207 231 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 251 275 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 344 364 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 370 394 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 406 425 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 437 460 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 58 462 Na_H_Exchanger. FT {ECO:0000259|Pfam:PF00999}. SQ SEQUENCE 889 AA; 97937 MW; E66634A0E609D711 CRC64; MWGLGARGPD RGLLLALALG GLARAGGVEV EPGGAHGESG GFQVVTFEWA HVQDPYVIAL WILVASLAKI GFHLSHKVTS VVPESALLIV LGLVLGGIVW AADHIASFTL TPTVFFFYLL PPIVLDAGYF MPNRLFFGNL GTILLYAVVG TVWNAATTGL SLYGVFLSGL MGDLQIGLLD FLLFGSLMAA VDPVAVLAVF EEVHVNEVLF IIVFGESLLN DAVTVVLYNV FESFVALGGD NVTGVDCVKG IVSFFVVSLG GTLVGVVFAF LLSLVTRFTK HVRIIEPGFV FIISYLSYLT SEMLSLSAIL AITFCGICCQ KYVKANISEQ SATTVRYTMK MLASSAETII FMFLGISAVN PFIWTWNTAF VLLTLVFISV YRAIGVVLQT WLLNRYRMVQ LEPIDQVVLS YGGLRGAVAF ALVVLLDGDK VKEKNLFVST TIIVVFFTVI FQGLTIKPLV QWLKVKRSEH REPRLNEKLH GRAFDHILSA IEDISGQIGH NYLRDKWSHF DRKFLSRVLM RRSAQKSRDR ILNVFHELNL KDAISYVAEG ERRGSLAFIR SPSTDNVVNV DFTPRSSTVE ASVSYLLREN VSAVCLDMQS LEQRRRSIRD AEDMVTHHTL QQYLYKPRQE YKHLYSRHEL TPTEDEKQDR EIFHRTMRKR LESFKSTKLG LNQNKKAAKL YKRERAQKRR NSSIPNGKLP MESPAQNFTI KEKDLELSDT EEPPNYDEEM SGGIEFLASV TKDTASDSPA GDTGSDTPLT GRSSPRHGPP TAAAAVPEKP QIPARLQRPR APSPASPTPA PAQNSESAAP APAEPPEGEP GAGPAPGAGP ERRGLPSAHA RSAAARRVHS RRSFQRPRAR RRPALLKLAS LPPSCHAPPH ALEQEETPL //