ID A0A2R8Y726_HUMAN Unreviewed; 659 AA. AC A0A2R8Y726; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 13-FEB-2019, entry version 5. DE SubName: Full=Paraplegin {ECO:0000313|Ensembl:ENSP00000495967}; GN Name=SPG7 {ECO:0000313|Ensembl:ENSP00000495967}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000495967, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000495967, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., RA Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [2] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [3] {ECO:0000313|Ensembl:ENSP00000495967} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC092123; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000647079; ENSP00000495967; ENSG00000197912. DR HGNC; HGNC:11237; SPG7. DR OpenTargets; ENSG00000197912; -. DR GeneTree; ENSGT00940000156329; -. DR Proteomes; UP000005640; Chromosome 16. DR ExpressionAtlas; A0A2R8Y726; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR HAMAP; MF_01458; FtsH; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR003959; ATPase_AAA_core. DR InterPro; IPR005936; FtsH. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR011546; Pept_M41_FtsH_extracell. DR InterPro; IPR000642; Peptidase_M41. DR InterPro; IPR037219; Peptidase_M41-like. DR Pfam; PF00004; AAA; 1. DR Pfam; PF06480; FtsH_ext; 1. DR Pfam; PF01434; Peptidase_M41; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF140990; SSF140990; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR TIGRFAMs; TIGR01241; FtsH_fam; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:A0A2R8Y726, KW ECO:0000213|MaxQB:A0A2R8Y726, ECO:0000213|PeptideAtlas:A0A2R8Y726}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 659 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015320087. FT TRANSMEM 118 136 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 205 345 AAA. {ECO:0000259|SMART:SM00382}. FT COILED 76 103 {ECO:0000256|SAM:Coils}. FT COILED 579 599 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 659 AA; 72954 MW; A2CFBB254AFE5BC6 CRC64; MYRERLRTLL VIAVVMSLLN ALSTSGGSIS WNDFVHEMLA KGEVQRVQVV PESDVVEVYL HPGAVVFGRP RLALMYRMQV ANIDKFEEKL RAAEDELNIE AKDRIPVSYK RTGFFGNALY SVGMTAVGLA ILWYVFRLAG MTGREGGFSA FNQLKMARFT IVDGKMGKGV SFKDVAGMHE AKLEVREFVD YLKSPERFLQ LGAKVPKGAL LLGPPGCGKT LLAKAVATEA QVPFLAMAGP EFVEVIGGLG AARVRSLFKE ARARAPCIVY IDEIDAVGKK RSTTMSGFSN TEEEQTLNQL LVEMDGMGTT DHVIVLASTN RADILDGALM RPGRLDRHVF IDLPTLQERR EIFEQHLKSL KLTQSSTFYS QRLAELTPGF SGADIANICN EAALHAAREG HTSVHTLNFE YAVERVLAGT AKKSKILSKE EQKVVAFHES GHALVGWMLE HTEAVMKVSI TPRTNAALGF AQMLPRDQHL FTKEQLFERM CMALGGRASE ALSFNEVTSG AQDDLRKVTR IAYSMVKQFG MAPGIGPISF PEAQEGLMGI GRRPFSQGLQ QMMDHEARLL VAKAYRHTEK VLQDNLDKLQ ALANALLEKE VINYEDIEAL IGPPPHGPKK MIAPQRWIDA QREKQDLGEE ETEETQQPPL GGEEPTWPK //