ID   A0A2R8Y6D7_HUMAN        Unreviewed;       230 AA.
AC   A0A2R8Y6D7;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 7.
DE   SubName: Full=Kv channel-interacting protein 2 {ECO:0000313|Ensembl:ENSP00000495474};
GN   Name=KCNIP2 {ECO:0000313|Ensembl:ENSP00000495474};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000495474, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000495474, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000495474}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
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DR   EMBL; AC010789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016871650.1; XM_017016161.1.
DR   UniGene; Hs.97044; -.
DR   Ensembl; ENST00000642874; ENSP00000495474; ENSG00000120049.
DR   GeneID; 30819; -.
DR   CTD; 30819; -.
DR   HGNC; HGNC:15522; KCNIP2.
DR   OpenTargets; ENSG00000120049; -.
DR   GeneTree; ENSGT00940000157798; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   ExpressionAtlas; A0A2R8Y6D7; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 3.
DR   PROSITE; PS50222; EF_HAND_2; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A2R8Y6D7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    230       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015337443.
FT   DOMAIN      100    135       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN      136    171       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN      184    219       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND     113    124       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND     149    160       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND     197    208       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   230 AA;  26625 MW;  08F4162069901EAF CRC64;
     MNLEGLEMVA VLVVLALFVK VLEQFGLFEP VSLEDSVDDE FELSTVCHRP EGLEQLQEQT
     KFTRKELQVL YRGFKNECPS GIVNEENFKQ IYSQFFPQGD SSTYATFLFN AFDTNHDGSV
     SFEDFVAGLS VILRGTVDDR LNWAFNLYDL NKDGCITKEE MLDIMKSIYD MMGKYTYPAL
     REEAPREHVE SFFQKMDRNK DGVVTIEEFI ESCQKDENIM RSMQLFDNVI
//