ID   A0A2R8Y5M7_HUMAN        Unreviewed;      1581 AA.
AC   A0A2R8Y5M7;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   SubName: Full=Adhesion G protein-coupled receptor B1 {ECO:0000313|Ensembl:ENSP00000494563};
GN   Name=ADGRB1 {ECO:0000313|Ensembl:ENSP00000494563};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000494563, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000494563, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [3] {ECO:0000313|Ensembl:ENSP00000494563}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|SAAS:SAAS00978931}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC134682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC139676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000643448; ENSP00000494563; ENSG00000181790.
DR   HGNC; HGNC:943; ADGRB1.
DR   OpenTargets; ENSG00000181790; -.
DR   GeneTree; ENSGT00940000157432; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   ExpressionAtlas; A0A2R8Y5M7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 5.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF02793; HRM; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01694; BAIPRECURSOR.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00209; TSP1; 5.
DR   SUPFAM; SSF82895; SSF82895; 5.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50092; TSP1; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A2R8Y5M7};
KW   Receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|SAAS:SAAS00978998};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31   1581       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015348853.
FT   TRANSMEM    946    967       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    979    998       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1010   1028       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1049   1068       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1088   1111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1132   1154       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      565    635       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
FT   DOMAIN      878    935       GPS. {ECO:0000259|PROSITE:PS50221}.
FT   DOMAIN      944   1185       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
FT   COILED     1486   1506       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1581 AA;  173216 MW;  16761D8D600836D6 CRC64;
     MRGQAAAPGP VWILAPLLLL LLLLGRRARA AAGADAGPGP EPCATLVQGK FFGYFSAAAV
     FPANASRCSW TLRNPDPRRY TLYMKVAKAP VPCSGPGRVR TYQFDSFLES TRTYLGVESF
     DEVLRLCDPS APLAFLQASK QFLQMRRQQP PQHDGLRPRA GPPGPTDDFS VEYLVVGNRN
     PSRAACQMLC RWLDACLAGS RSSHPCGIMQ TPCACLGGEA GGPAAGPLAP RGDVCLRDAV
     AGGPENCLTS LTQDRGGHGA TGGWKLWSLW GECTRDCGGG LQTRTRTCLP APGVEGGGCE
     GVLEEGRQCN REACGPAGRT SSRSQSLRST DARRREELGD ELQQFGFPAP QTGDPAAEEW
     SPWSVCSSTC GEGWQTRTRF CVSSSYSTQC SGPLREQRLC NNSAVCPVHG AWDEWSPWSL
     CSSTCGRGFR DRTRTCRPPQ FGGNPCEGPE KQTKFCNIAL CPVDGNWNEW SSWSACSASC
     SQGRQQRTRE CNGPSYGGAE CQGHWVETRD CFLQQCPVDG KWQAWASWGS CSVTCGAGSQ
     RRERVCSGPF FGGAACQGPQ DEYRQCGTQR CPEPHEICDE DNFGAVIWKE TPAGEVAAVR
     CPRNATGLIL RRCELDEEGI AYWEPPTYIR CVSIDYRNIQ MMTREHLAKA QRGLPGEGVS
     EVIQTLVEIS QDGTSYSGDL LSTIDVLRNM TEIFRRAYYS PTPGDVQNFV QILSNLLAEE
     NRDKWEEAQL AGPNAKELFR LVEDFVDVIG FRMKDLRDAY QVTDNLVLSI HKLPASGATD
     ISFPMKGWRA TGDWAKVPED RVTVSKSVFS TGLTEADEAS VFVVGTVLYR NLGSFLALQR
     NTTVLNSKVI SVTVKPPPRS LRTPLEIEFA HMYNGTTNQT CILWDETDVP SSSAPPQLGP
     WSWRGCRTVP LDALRTRCLC DRLSTFAILA QLSADANMEK ATLPSVTLIV GCGVSSLTLL
     MLVIIYVSVW RYIRSERSVI LINFCLSIIS SNALILIGQT QTRNKVVCTL VAAFLHFFFL
     SSFCWVLTEA WQSYMAVTGH LRNRLIRKRF LCLGWGLPAL VVAISVGFTK AKGYSTMNYC
     WLSLEGGLLY AFVGPAAAVV LVNMVIGILV FNKLVSKDGI TDKKLKERAG ASLWSSCVVL
     PLLALTWMSA VLAVTDRRSA LFQILFAVFD SLEGFVIVMV HCILRREVQD AVKCRVVDRQ
     EEGNGDSGGS FQNGHAQLMT DFEKDVDLAC RSVLNKDIAA CRTATITGTL KRPSLPEEEK
     LKLAHAKGPP TNFNSLPANV SKLHLHGSPR YPGGPLPDFP NHSLTLKRDK APKSSFVGDG
     DIFKKLDSEL SRAQEKALDT SYVILPTATA TLRPKPKEEP KYSIHIDQMP QTRLIHLSTA
     PEASLPARSP PSRQPPSGGP PEAPPAQPPP PPPPPPPPPQ QPLPPPPNLE PAPPSLGDPG
     EPAAHPGPST GPSTKNENVA TLSVSSLERR KSRYAELDFE KIMHTRKRHQ DMFQDLNRKL
     QHAAEKDKEV LGPDSKPEKQ QTPNKRPWES LRKAHGTPTW VKKELEPLQP SPLELRSVEW
     ERSGATIPLV GQDIIDLQTE V
//