ID   A0A2R8Y5J6_HUMAN        Unreviewed;       481 AA.
AC   A0A2R8Y5J6;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 4.
DE   SubName: Full=Epsilon-sarcoglycan {ECO:0000313|Ensembl:ENSP00000494587};
DE   Flags: Fragment;
GN   Name=SGCE {ECO:0000313|Ensembl:ENSP00000494587};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000494587, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000494587, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000494587}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
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DR   EMBL; AC002528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC096662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000646265; ENSP00000494587; ENSG00000127990.
DR   HGNC; HGNC:10808; SGCE.
DR   OpenTargets; ENSG00000127990; -.
DR   GeneTree; ENSGT00390000005672; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   ExpressionAtlas; A0A2R8Y5J6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016012; C:sarcoglycan complex; IEA:InterPro.
DR   InterPro; IPR006644; Cadg.
DR   InterPro; IPR008908; Sarcoglycan_alpha/epsilon.
DR   InterPro; IPR030775; SGCE.
DR   PANTHER; PTHR10132; PTHR10132; 1.
DR   PANTHER; PTHR10132:SF17; PTHR10132:SF17; 1.
DR   Pfam; PF05510; Sarcoglycan_2; 1.
DR   SMART; SM00736; CADG; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A2R8Y5J6,
KW   ECO:0000213|MaxQB:A0A2R8Y5J6, ECO:0000213|PeptideAtlas:A0A2R8Y5J6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     39       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        40    481       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015350820.
FT   TRANSMEM    347    368       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       79    187       CADG. {ECO:0000259|SMART:SM00736}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000494587}.
SQ   SEQUENCE   481 AA;  54452 MW;  6828697A07592E5B CRC64;
     XELGDPCAWT GQGRGTRRMS PATTGTFLLT AFLLSCADGI NGTVNWKTRQ ANNFIISRKM
     AAGMKDVYSI FSKVHSDRNV YPSAGVLFVH VLEREYFKGE FPPYPKPGEI SNDPITFNTN
     LMGYPDRPGW LRYIQRTPYS DGVLYGSPTA ENVGKPTIIE ITAYNRRTFE TARHNLIINI
     MSAEDFPLPY QAEFFIKNMN VEEMLASEVL GDFLGAVKNV WQPERLNAIN ITSALDRGGR
     VPLPINDLKE GVYVMVGADV PFSSCLREVE NPQNQLRCSQ EMEPVITCDK KFRTQFYIDW
     CKISLVDKTK QVSTYQEVIR GEGILPDGGE YKPPSDSLKS RDYYTDFLIT LAVPSAVALV
     LFLILAYIMC CRREGVIQLV HHSAIQKSTK ELRDMSKNRE IAWPLSTLPV FHPVTGEIIP
     PLHTDNYDST NMPLMQTQQN LPHQTQIPQQ QTTGDFRLTT FQRFEVNGIP EERKLTEAMN
     L
//