ID   A0A2R8Y596_HUMAN        Unreviewed;       916 AA.
AC   A0A2R8Y596;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   05-DEC-2018, entry version 4.
DE   SubName: Full=Breast cancer anti-estrogen resistance protein 1 {ECO:0000313|Ensembl:ENSP00000494638};
GN   Name=BCAR1 {ECO:0000313|Ensembl:ENSP00000494638};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000494638, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000494638, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [3] {ECO:0000213|PubMed:20068231}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA   Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full
RT   phosphorylation site occupancy during mitosis.";
RL   Sci. Signal. 3:ra3-RA3(2010).
RN   [4] {ECO:0000213|PubMed:21406692}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA   Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA   Blagoev B.;
RT   "System-wide temporal characterization of the proteome and
RT   phosphoproteome of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:rs3-RS3(2011).
RN   [5] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [6] {ECO:0000313|Ensembl:ENSP00000494638}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; FO681525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000644430; ENSP00000494638; ENSG00000285460.
DR   HGNC; HGNC:971; BCAR1.
DR   Proteomes; UP000005640; Chromosome 16.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd12001; SH3_BCAR1; 1.
DR   Gene3D; 1.20.120.830; -; 1.
DR   InterPro; IPR028848; BCAR1.
DR   InterPro; IPR035745; BCAR1_SH3.
DR   InterPro; IPR021901; CAS_C.
DR   InterPro; IPR037362; CAS_fam.
DR   InterPro; IPR014928; Serine_rich_dom.
DR   InterPro; IPR038319; Serine_rich_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR10654; PTHR10654; 1.
DR   PANTHER; PTHR10654:SF15; PTHR10654:SF15; 1.
DR   Pfam; PF12026; CAS_C; 1.
DR   Pfam; PF08824; Serine_rich; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A2R8Y596,
KW   ECO:0000213|MaxQB:A0A2R8Y596, ECO:0000213|PeptideAtlas:A0A2R8Y596};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    916       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015352734.
FT   DOMAIN       49    111       SH3. {ECO:0000259|PROSITE:PS50002}.
SQ   SEQUENCE   916 AA;  97907 MW;  5134CC166177823E CRC64;
     MPAKPFLSSV LLSWKVLDFS GPGPQGTGQP CSCGHWAEGQ GGPPEPAGGP NVLAKALYDN
     VAESPDELSF RKGDIMTVLE QDTQGLDGWW LCSLHGRQGI VPGNRLKILV GMYDKKPAGP
     GPGPPATPAQ PQPGLHAPAP PASQYTPMLP NTYQPQPDSV YLVPTPSKAQ QGLYQVPGPS
     PQFQSPPAKQ TSTFSKQTPH HPFPSPATDL YQVPPGPGGP AQDIYQVPPS AGMGHDIYQV
     PPSMDTRSWE GTKPPAKVVV PTRVGQGYVY EAAQPEQDEY DIPRHLLAPG PQDIYDVPPV
     RGLLPSQYGQ EVYDTPPMAV KGPNGRDPLL EVYDVPPSVE KGLPPSNHHA VYDVPPSVSK
     DVPDGPLLRE ETYDVPPAFA KAKPFDPART PLVLAAPPPD SPPAEDVYDV PPPAPDLYDV
     PPGLRRPGPG TLYDVPRERV LPPEVADGGV VDSGVYAVPP PAEREAPAEG KRLSASSTGS
     TRSSQSASSL EVAGPGREPL ELEVAVEALA RLQQGVSATV AHLLDLAGSA GATGSWRSPS
     EPQEPLVQDL QAAVAAVQSA VHELLEFARS AVGNAAHTSD RALHAKLSRQ LQKMEDVHQT
     LVAHGQALDA GRGSSGATLE DLDRLVACSR AVPEDAKQLA SFLHGNASLL FRRTKATAPG
     PEGGGTLHPN PTDKTSSIQS RPLPSPPKFT SQDSPDGQYE NSEGGWMEDY DYVHLQGKEE
     FEKTQKELLE KGSITRQGKS QLELQQLKQF ERLEQEVSRP IDHDLANWTP AQPLAPGRTG
     GLGPSDRQLL LFYLEQCEAN LTTLTNAVDA FFTAVATNQP PKIFVAHSKF VILSAHKLVF
     IGDTLSRQAK AADVRSQVTH YSNLLCDLLR GIVATTKAAA LQYPSPSAAQ DMVERVKELG
     HSTQQFRRVL GQLAAA
//