ID   A0A2R8Y4T1_HUMAN        Unreviewed;      1860 AA.
AC   A0A2R8Y4T1;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 5.
DE   SubName: Full=Tensin-1 {ECO:0000313|Ensembl:ENSP00000493967};
GN   Name=TNS1 {ECO:0000313|Ensembl:ENSP00000493967};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000493967, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000493967, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:18088087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18088087; DOI=10.1021/pr0704130;
RA   Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA   Schutz C., Walter U., Gambaryan S., Sickmann A.;
RT   "Phosphoproteome of resting human platelets.";
RL   J. Proteome Res. 7:526-534(2008).
RN   [3] {ECO:0000213|PubMed:18220336}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18220336; DOI=10.1021/pr0705441;
RA   Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.;
RT   "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for
RT   efficient phosphoproteomic analysis.";
RL   J. Proteome Res. 7:1346-1351(2008).
RN   [4] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [5] {ECO:0000213|PubMed:20068231}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA   Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full
RT   phosphorylation site occupancy during mitosis.";
RL   Sci. Signal. 3:ra3-RA3(2010).
RN   [6] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [7] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [8] {ECO:0000313|Ensembl:ENSP00000493967}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
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DR   EMBL; AC009469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000646520; ENSP00000493967; ENSG00000079308.
DR   HGNC; HGNC:11973; TNS1.
DR   OpenTargets; ENSG00000079308; -.
DR   GeneTree; ENSGT00940000155400; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   ExpressionAtlas; A0A2R8Y4T1; baseline and differential.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd01213; PTB_tensin; 1.
DR   CDD; cd09927; SH2_Tensin_like; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR013625; PTB.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR014020; Tensin_C2-dom.
DR   InterPro; IPR035012; Tensin_like_SH2.
DR   InterPro; IPR029023; Tensin_phosphatase.
DR   InterPro; IPR033929; Tensin_PTB.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   Pfam; PF08416; PTB; 1.
DR   Pfam; PF10409; PTEN_C2; 1.
DR   Pfam; PF00017; SH2; 1.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM01326; PTEN_C2; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS51182; C2_TENSIN; 1.
DR   PROSITE; PS51181; PPASE_TENSIN; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00515414};
KW   Proteomics identification {ECO:0000213|EPD:A0A2R8Y4T1,
KW   ECO:0000213|MaxQB:A0A2R8Y4T1, ECO:0000213|PeptideAtlas:A0A2R8Y4T1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|SAAS:SAAS00515409}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31   1860       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015328794.
FT   DOMAIN       41     88       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      150    322       Phosphatase tensin-type.
FT                                {ECO:0000259|PROSITE:PS51181}.
FT   DOMAIN      327    453       C2 tensin-type.
FT                                {ECO:0000259|PROSITE:PS51182}.
FT   DOMAIN     1588   1697       SH2. {ECO:0000259|PROSITE:PS50001}.
SQ   SEQUENCE   1860 AA;  199551 MW;  6A63E761AA881CDC CRC64;
     MTRLSWCFSC VIRWGKYLFS CLLPLRFCLR SQPEDLEAPK THRFKVKTFK KVKPCGICRQ
     VITQEGCTCK VCSFSCHRKC QAKVAAPCVP PSNHELVPIT TENAPKNVVD KGEGASRGGN
     TRKSLEDNGS TRVTPSVQPH LQPIRNMSVS RTMEDSCELD LVYVTERIIA VSFPSTANEE
     NFRSNLREVA QMLKSKHGGN YLLFNLSERR PDITKLHAKV LEFGWPDLHT PALEKICSIC
     KAMDTWLNAD PHNVVVLHNK GNRGRIGVVI AAYMHYSNIS ASADQALDRF AMKRFYEDKI
     VPIGQPSQRR YVHYFSGLLS GSIKMNNKPL FLHHVIMHGI PNFESKGGCR PFLRIYQAMQ
     PVYTSGIYNI PGDSQTSVCI TIEPGLLLKG DILLKCYHKK FRSPARDVIF RVQFHTCAIH
     DLGVVFGKED LDDAFKDDRF PEYGKVEFVF SYGPEKIQGM EHLENGPSVS VDYNTSDPLI
     RWDSYDNFSG HRDDGMEEVV GHTQGPLDGS LYAKVKKKDS LHGSTGAVNA TRPTLSATPN
     HVEHTLSVSS DSGNSTASTK TDKTDEPVPG ASSATAALSP QEKRELDRLL SGFGLEREKQ
     GAMYHTQHLR SRPAGGSAVP SSGRHVVPAQ VHVNGGALAS ERETDILDDE LPNQDGHSAG
     SMGTLSSLDG VTNTSEGGYP EALSPLTNGL DKSYPMEPMV NGGGYPYESA SRAGPAHAGH
     TAPMRPSYSA QEGLAGYQRE GPHPAWPQPV TTSHYAHDPS GMFRSQSFSE AEPQLPPAPV
     RGGSSREAVQ RGLNSWQQQQ QQQQQPRPPP RQQERAHLES LVASRPSPQP LAETPIPSLP
     EFPRAASQQE IEQSIETLNM LMLDLEPASA AAPLHKSQSV PGAWPGASPL SSQPLSGSSR
     QSHPLTQSRS GYIPSGHSLG TPEPAPRASL ESVPPGRSYS PYDYQPCLAG PNQDFHSKSP
     ASSSLPAFLP TTHSPPGPQQ PPASLPGLTA QPLLSPKEAT SDPSRTPEEE PLNLEGLVAH
     RVAGVQAREK QPAEPPAPLR RRAASDGQYE NQSPEATSPR SPGVRSPVQC VSPELALTIA
     LNPGGRPKEP HLHSYKEAFE EMEGTSPSSP PPSGVRSPPG LAKTPLSALG LKPHNPADIL
     LHPTGEPRSY VESVARTAVA GPRAQDSEPK SFSAPATQAY GHEIPLRNGT LGGSFVSPSP
     LSTSSPILSA DSTSVGSFPS GESSDQGPRT PTQPLLESGF RSGSLGQPSP SAQRNYQSSS
     PLPTVGSSYS SPDYSLQHFS SSPESQARAQ FSVAGVHTVP GSPQARHRTV GTNTPPSPGF
     GWRAINPSMA APSSPSLSHH QMMGPPGTGF HGSTVSSPQS SAATTPGSPS LCRHPAGVYQ
     VSGLHNKVAT TPGSPSLGRH PGAHQGNLAS GLHSNAIASP GSPSLGRHLG GSGSVVPGSP
     CLDRHVAYGG YSTPEDRRPT LSRQSSASGY QAPSTPSFPV SPAYYPGLSS PATSPSPDSA
     AFRQGSPTPA LPEKRRMSVG DRAGSLPNYA TINGKVSSPV ASGMSSPSGG STVSFSHTLP
     DFSKYSMPDN SPETRAKVKF VQDTSKYWYK PEISREQAIA LLKDQEPGAF IIRDSHSFRG
     AYGLAMKVSS PPPTIMQQNK KGDMTHELVR HFLIETGPRG VKLKGCPNEP NFGSLSALVY
     QHSIIPLALP CKLVIPNRDP TDESKDSSGP ANSTADLLKQ GAACNVLFVN SVDMESLTGP
     QAISKATSET LAADPTPAAT IVHFKVSAQG ITLTDNQRKL FFRRHYPLNT VTFCDLDPQE
     RKWMKTEGGA PAKLFGFVAR KQGSTTDNAC HLFAELDPNQ PASAIVNFVS KVMLNAGQKR
//