ID   A0A2R8Y3T0_HUMAN        Unreviewed;       513 AA.
AC   A0A2R8Y3T0;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   13-FEB-2019, entry version 5.
DE   SubName: Full=Cochlin {ECO:0000313|Ensembl:ENSP00000493569};
GN   Name=COCH {ECO:0000313|Ensembl:ENSP00000493569};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000493569, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000493569, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000493569}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
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DR   EMBL; AL049830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000555117; ENSP00000493569; ENSG00000100473.
DR   HGNC; HGNC:2180; COCH.
DR   OpenTargets; ENSG00000100473; -.
DR   GeneTree; ENSGT00940000159386; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   ExpressionAtlas; A0A2R8Y3T0; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR   GO; GO:0045089; P:positive regulation of innate immune response; IEA:InterPro.
DR   Gene3D; 2.170.130.20; -; 1.
DR   Gene3D; 3.40.50.410; -; 2.
DR   InterPro; IPR030743; Cochlin.
DR   InterPro; IPR004043; LCCL.
DR   InterPro; IPR036609; LCCL_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR44729; PTHR44729; 1.
DR   Pfam; PF03815; LCCL; 1.
DR   Pfam; PF00092; VWA; 2.
DR   SMART; SM00603; LCCL; 1.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF53300; SSF53300; 2.
DR   SUPFAM; SSF69848; SSF69848; 1.
DR   PROSITE; PS50820; LCCL; 1.
DR   PROSITE; PS50234; VWFA; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A2R8Y3T0,
KW   ECO:0000213|MaxQB:A0A2R8Y3T0, ECO:0000213|PeptideAtlas:A0A2R8Y3T0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    513       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015343116.
FT   DOMAIN       28    121       LCCL. {ECO:0000259|PROSITE:PS50820}.
FT   DOMAIN      165    369       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      386    513       VWFA. {ECO:0000259|PROSITE:PS50234}.
SQ   SEQUENCE   513 AA;  55406 MW;  7AB13CAA7A46D433 CRC64;
     MSAAWIPALG LGVCLLLLPG PAGSEGAAPI AITCFTRGLD IRKEKADVLC PGGCPLEEFS
     VYGNIVYASV SSICGAAVHR GVISNSGGPV RVYSLPGREN YSSVDANGIQ SQMLSRWSAS
     FTVTKGKSST QEATGQAVST AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR
     FNLQKNFVGK VALMLGIGTE GPHVGLVQAS EHPKIEFYLK NFTSAKDVLF AIKEVGFRGG
     NSNTDVAERM SSTTVDSEER LLRGKALKHT AQKFFTVDAG VRKGIPKVVV VFIDGWPSDD
     IEEAGIVARE FGVNVFIVSV AKPIPEELGM VQDVTFVDKA VCRNNGFFSY HMPNWFGTTK
     YVKPLVQKLC THEQMMCSKT CYNSVNIAFL IDGSSSVGDS NFRLMLEFVS NIAKTFEISD
     IGAKIAAVQF TYDQRTEFSF TDYSTKENVL AVIRNIRYMS GGTATGDAIS FTVRNVFGPI
     RESPNKNFLV IVTDGQSYDD VQGPAAAAHD AAK
//