ID A0A1X7SBZ8_HUMAN Unreviewed; 507 AA. AC A0A1X7SBZ8; DT 05-JUL-2017, integrated into UniProtKB/TrEMBL. DT 05-JUL-2017, sequence version 1. DT 05-DEC-2018, entry version 10. DE SubName: Full=Gamma-aminobutyric acid receptor subunit gamma-2 {ECO:0000313|Ensembl:ENSP00000354651}; GN Name=GABRG2 {ECO:0000313|Ensembl:ENSP00000354651}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000354651, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000354651, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000354651} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2017) to UniProtKB. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) CC family. {ECO:0000256|RuleBase:RU000687, CC ECO:0000256|SAAS:SAAS00978283}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC008611; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091926; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091984; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A1X7SBZ8; -. DR Ensembl; ENST00000361925; ENSP00000354651; ENSG00000113327. DR HGNC; HGNC:4087; GABRG2. DR OpenTargets; ENSG00000113327; -. DR GeneTree; ENSGT00940000156685; -. DR ChiTaRS; GABRG2; human. DR Proteomes; UP000005640; Chromosome 5. DR ExpressionAtlas; A0A1X7SBZ8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro. DR GO; GO:0006821; P:chloride transport; IEA:InterPro. DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 2. DR InterPro; IPR006028; GABAA/Glycine_rcpt. DR InterPro; IPR005439; GABBAg2_rcpt. DR InterPro; IPR005437; GABBAg_rcpt. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR PANTHER; PTHR18945; PTHR18945; 2. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00253; GABAARECEPTR. DR PRINTS; PR01620; GABAARGAMMA. DR PRINTS; PR01622; GABAARGAMMA2. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 1: Evidence at protein level; KW Cell membrane {ECO:0000256|SAAS:SAAS00081375}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00766067}; KW Ion channel {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}; KW Ion transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}; KW Membrane {ECO:0000256|SAAS:SAAS00081375, KW ECO:0000256|SAAS:SAAS00978768, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A1X7SBZ8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}. FT SIGNAL 1 40 {ECO:0000256|SAM:SignalP}. FT CHAIN 41 507 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5010881442. FT TRANSMEM 312 336 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 377 400 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 487 506 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 69 213 Neur_chan_LBD. FT {ECO:0000259|Pfam:PF02931}. FT DOMAIN 319 440 Neur_chan_memb. FT {ECO:0000259|Pfam:PF02932}. SQ SEQUENCE 507 AA; 58321 MW; 55E17E988CFFBACD CRC64; MSSPNIWSTG SSVYSTPVFS QKMTVWILLL LSLYPGFTSQ KSDDDYEDYA SNKTWVLTPK VPEGDVTVIL NNLLEGYDNK LRPDIGVKPT LIHTDMYVNS IGPVNAINME YTIDIFFAQT WYDRRLKFNS TIKVLRLNSN MVGKIWIPDT FFRNSKKADA HWITTPNRML RIWNDGRVLY TLRLTIDAEC QLQLHNFPMD EHSCPLEFSS WSRSIAQAGM CSGVISAHYS LRFWGSTDPP TLASRVAGIS DGYPREEIVY QWKRSSVEVG DTRSWRLYQF SFVGLRNTTE VVKTTSGDYV VMSVYFDLSR RMGYFTIQTY IPCTLIVVLS WVSFWINKDA VPARTSLGIT TVLTMTTLST IARKSLPKVS YVTAMDLFVS VCFIFVFSAL VEYGTLHYFV SNRKPSKDKD KKKKNPAPTI DIRPRSATIQ MNNATHLQER DEEYGYECLD GKDCASFFCC FEDCRTGAWR HGRIHIRIAK MDSYARIFFP TAFCLFNLVY WVSYLYL //