ID   A0A1X7SBX3_HUMAN        Unreviewed;      1001 AA.
AC   A0A1X7SBX3;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   05-DEC-2018, entry version 9.
DE   SubName: Full=Extracellular calcium-sensing receptor {ECO:0000313|Ensembl:ENSP00000418685};
GN   Name=CASR {ECO:0000313|Ensembl:ENSP00000418685};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000418685, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000418685, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000418685}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00543559}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00543559}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC       {ECO:0000256|SAAS:SAAS00547813}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC068630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC083798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; A0A1X7SBX3; -.
DR   Ensembl; ENST00000490131; ENSP00000418685; ENSG00000036828.
DR   HGNC; HGNC:1514; CASR.
DR   OpenTargets; ENSG00000036828; -.
DR   GeneTree; ENSGT00940000157596; -.
DR   ChiTaRS; CASR; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   ExpressionAtlas; A0A1X7SBX3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.50.30; -; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; PTHR24061; 2.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00592; CASENSINGR.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR   PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00138752};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00497975};
KW   Membrane {ECO:0000256|SAAS:SAAS00138752,
KW   ECO:0000256|SAAS:SAAS00425515, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A1X7SBX3};
KW   Receptor {ECO:0000256|SAAS:SAAS00497975};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|SAAS:SAAS00497975};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00425515,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00425515,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20   1001       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012372216.
FT   TRANSMEM    535    560       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    572    593       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    605    627       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    648    667       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    693    715       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    727    749       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    755    777       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      535    799       G_PROTEIN_RECEP_F3_4.
FT                                {ECO:0000259|PROSITE:PS50259}.
SQ   SEQUENCE   1001 AA;  111695 MW;  C3BB07D16A6A2B0D CRC64;
     MAFYSCCWVL LALTWHTSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD LKSRPESVEC
     IRYNFRGFRW LQAMIFAIEE INSSPALLPN LTLGYRIFDT CNTVSKALEA TLSFVAQNKI
     DSLNLDEFCN CSEHIPSTIA VVGATGSGVS TAVANLLGLF YIPQVSYASS SRLLSNKNQF
     KSFLRTIPND EHQATAMADI IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS
     ELISQYSDEE EIQHVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG KIWLASEAWA
     SSSLIAMPQY FHVVGGTIGF ALKAGQIPGF REFLKKVHPR KSVHNGFAKE FWEETFNCHL
     QEGAKGPLPV DTFLRGHEES GDRFSNSSTA FRPLCTGDEN ISSVETPYID YTHLRISYNV
     YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA DIKKVEAWQV PFSNCSRDCL AGTRKGIIEG
     EPTCCFECVE CPDGEYSDET DASACNKCPD DFWSNENHTS CIAKEIEFLS WTEPFGIALT
     LFAVLGIFLT AFVLGVFIKF RNTPIVKATN RELSYLLLFS LLCCFSSSLF FIGEPQDWTC
     RLRQPAFGIS FVLCISCILV KTNRVLLVFE AKIPTSFHRK WWGLNLQFLL VFLCTFMQIV
     ICVIWLYTAP PSSYRNQELE DEIIFITCHE GSLMALGFLI GYTCLLAAIC FFFAFKSRKL
     PENFNEAKFI TFSMLIFFIV WISFIPAYAS TYGKFVSAVE VIAILAASFG LLACIFFNKI
     YIILFKPSRN TIEEVRCSTA AHAFKVAARA TLRRSNVSRK RSSSLGGSTG STPSSSISSK
     SNSEDPFPQP ERQKQQQPLA LTQQEQQQQP LTLPQQQRSQ QQPRCKQKVI FGSGTVTFSL
     SFDEPQKNAM AHRNSTHQNS LEAQKSSDTL TRHEPLLPLQ CGETDLDLTV QETGLQGPVG
     GDQRPEVEDP EELSPALVVS SSQSFVISGG GSTVTENVVN S
//