ID   A0A1X7SBT4_HUMAN        Unreviewed;       258 AA.
AC   A0A1X7SBT4;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   16-JAN-2019, entry version 8.
DE   SubName: Full=Phosphatidylinositol-glycan biosynthesis class X protein {ECO:0000313|Ensembl:ENSP00000376192};
GN   Name=PIGX {ECO:0000313|Ensembl:ENSP00000376192};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000376192, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000376192, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000376192}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2017) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC055725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; A0A1X7SBT4; -.
DR   Ensembl; ENST00000392391; ENSP00000376192; ENSG00000163964.
DR   HGNC; HGNC:26046; PIGX.
DR   OpenTargets; ENSG00000163964; -.
DR   GeneTree; ENSGT00390000017679; -.
DR   ChiTaRS; PIGX; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   ExpressionAtlas; A0A1X7SBT4; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:InterPro.
DR   InterPro; IPR013233; PIG-X/PBN1.
DR   InterPro; IPR040039; PIGX.
DR   PANTHER; PTHR28650; PTHR28650; 1.
DR   Pfam; PF08320; PIG-X; 1.
DR   SMART; SM00780; PIG-X; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A1X7SBT4,
KW   ECO:0000213|PeptideAtlas:A0A1X7SBT4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    258       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010873644.
FT   TRANSMEM    228    251       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   258 AA;  28770 MW;  55D3DED597E047E7 CRC64;
     LAARVAAVRA AAWLLLGAAT GLTRGPAAAF TAARSDAGIR AMCSEIILRQ EVLKDGFHRD
     LLIKVKFGES IEDLHTCRLL IKQDIPAGLY VDPYELASLR ERNITEAVMV SENFDIEAPN
     YLSKESEVLI YARRDSQCID CFQAFLPVHC RYHRPHSEDG EASIVVNNPD LLMFCDQEFP
     ILKCWAHSEV AAPCALENED ICQWNKMKYK SVYKNVILQV PVGLTVHTSL VCSVTLLITI
     LCSTLILVAV FKYGHFSL
//