ID A0A1X7SBS5_HUMAN Unreviewed; 476 AA. AC A0A1X7SBS5; DT 05-JUL-2017, integrated into UniProtKB/TrEMBL. DT 05-JUL-2017, sequence version 1. DT 05-DEC-2018, entry version 9. DE SubName: Full=Gamma-aminobutyric acid receptor subunit gamma-2 {ECO:0000313|Ensembl:ENSP00000349000}; DE Flags: Fragment; GN Name=GABRG2 {ECO:0000313|Ensembl:ENSP00000349000}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000349000, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000349000, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000349000} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2017) to UniProtKB. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) CC family. {ECO:0000256|RuleBase:RU000687, CC ECO:0000256|SAAS:SAAS00978283}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC008611; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091926; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091984; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A1X7SBS5; -. DR Ensembl; ENST00000356592; ENSP00000349000; ENSG00000113327. DR HGNC; HGNC:4087; GABRG2. DR OpenTargets; ENSG00000113327; -. DR GeneTree; ENSGT00940000156685; -. DR ChiTaRS; GABRG2; human. DR Proteomes; UP000005640; Chromosome 5. DR ExpressionAtlas; A0A1X7SBS5; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro. DR GO; GO:0006821; P:chloride transport; IEA:InterPro. DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006028; GABAA/Glycine_rcpt. DR InterPro; IPR005439; GABBAg2_rcpt. DR InterPro; IPR005437; GABBAg_rcpt. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR PANTHER; PTHR18945; PTHR18945; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00253; GABAARECEPTR. DR PRINTS; PR01620; GABAARGAMMA. DR PRINTS; PR01622; GABAARGAMMA2. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 1: Evidence at protein level; KW Cell membrane {ECO:0000256|SAAS:SAAS00081375}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Ion channel {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}; KW Ion transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}; KW Membrane {ECO:0000256|SAAS:SAAS00081375, KW ECO:0000256|SAAS:SAAS00978768, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A1X7SBS5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 476 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012869377. FT TRANSMEM 281 298 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 338 361 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 456 475 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 57 273 Neur_chan_LBD. FT {ECO:0000259|Pfam:PF02931}. FT DOMAIN 280 377 Neur_chan_memb. FT {ECO:0000259|Pfam:PF02932}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000349000}. SQ SEQUENCE 476 AA; 55481 MW; 7F50BE331FF3DB41 CRC64; XYSTPVFSQK MTVWILLLLS LYPGFTSQKS DDDYEDYASN KTWVLTPKVP EGDVTVILNN LLEGYDNKLR PDIGVKPTLI HTDMYVNSIG PVNAINMEYT IDIFFAQTWY DRRLKFNSTI KVLRLNSNMV GKIWIPDTFF RNSKKADAHW ITTPNRMLRI WNDGRVLYTL RLTIDAECQL QLHNFPMDEH SCPLEFSSYG YPREEIVYQW KRSSVEVGDT RSWRLYQFSF VGLRNTTEVV KTTSEDKLHE ILVNLTLGDY VVMSVYFDLS RRMGYFTIQT YIPCTLIVVL SWVSFWINKD AVPARTSLGI TTVLTMTTLS TIARKSLPKV SYVTAMDLFV SVCFIFVFSA LVEYGTLHYF VSNRKPSKDK DKKKKNPLLR MFSFKAPTID IRPRSATIQM NNATHLQERD EEYGYECLDG KDCASFFCCF EDCRTGAWRH GRIHIRIAKM DSYARIFFPT AFCLFNLVYW VSYLYL //