ID   A0A1X7SBR9_HUMAN        Unreviewed;      1213 AA.
AC   A0A1X7SBR9;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   16-JAN-2019, entry version 16.
DE   SubName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 19 {ECO:0000313|Ensembl:ENSP00000274487};
GN   Name=ADAMTS19 {ECO:0000313|Ensembl:ENSP00000274487};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000274487, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000274487, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000274487}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2017) to UniProtKB.
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DR   EMBL; AC008425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC129713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_598377.4; NM_133638.4.
DR   UniGene; Hs.23751; -.
DR   Ensembl; ENST00000274487; ENSP00000274487; ENSG00000145808.
DR   GeneID; 171019; -.
DR   KEGG; hsa:171019; -.
DR   CTD; 171019; -.
DR   HGNC; HGNC:17111; ADAMTS19.
DR   OpenTargets; ENSG00000145808; -.
DR   GeneTree; ENSGT00940000161018; -.
DR   KO; K08633; -.
DR   OrthoDB; 125522at2759; -.
DR   ChiTaRS; ADAMTS19; human.
DR   GenomeRNAi; 171019; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   ExpressionAtlas; A0A1X7SBR9; baseline and differential.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 5.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00209; TSP1; 5.
DR   SUPFAM; SSF82895; SSF82895; 5.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00517240};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A1X7SBR9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28   1213       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010852630.
FT   DOMAIN      331    551       Peptidase M12B.
FT                                {ECO:0000259|PROSITE:PS50215}.
FT   DOMAIN     1166   1205       PLAC. {ECO:0000259|PROSITE:PS50900}.
SQ   SEQUENCE   1213 AA;  134764 MW;  A274B4147302F03F CRC64;
     MGKNREMRLT HICCCCLLYQ LGFLSNGIVS ELQFAPDREE WEVVFPALWR REPVDPAGGS
     GGSADPGWVR GVGGGGSARA QAAGSSREVR SVAPVPLEEP VEGRSESRLR PPPPSEGEED
     EELESQELPR GSSGAAALSP GAPASWQPPP PPQPPPSPPP AQHAEPDGDE VLLRIPAFSR
     DLYLLLRRDG RFLAPRFAVE QRPNPGPGPT GAASAPQPPA PPDAGCFYTG AVLRHPGSLA
     SFSTCGGGLM GFIQLNEDFI FIEPLNDTMA ITGHPHRVYR QKRSMEEKVT EKSALHSHYC
     GIISDKGRPR SRKIAESGRG KRYSYKLPQE YNIETVVVAD PAMVSYHGAD AARRFILTIL
     NMVFNLFQHK SLSVQVNLRV IKLILLHETP PELYIGHHGE KMLESFCKWQ HEEFGKKNDI
     HLEMSTNWGE DMTSVDAAIL ITRKDFCVHK DEPCDTVGIA YLSGMCSEKR KCIIAEDNGL
     NLAFTIAHEM GHNMGINHDN DHPSCADGLH IMSGEWIKGQ NLGDVSWSRC SKEDLERFLR
     SKASNCLLQT NPQSVNSVMV PSKLPGMTYT ADEQCQILFG PLASFCQEMQ HVICTGLWCK
     VEGEKECRTK LDPPMDGTDC DLGKWCKAGE CTSRTSAPEH LAGEWSLWSP CSRTCSAGIS
     SRERKCPGLD SEARDCNGPR KQYRICENPP CPAGLPGFRD WQCQAYSVRT SSPKHILQWQ
     AVLDEEKPCA LFCSPVGKEQ PILLSEKVMD GTSCGYQGLD ICANGRCQKV GCDGLLGSLA
     REDHCGVCNG NGKSCKIIKG DFNHTRGAGY VEVLVIPAGA RRIKVVEEKP AHSYLALRDA
     GKQSINSDWK IEHSGAFNLA GTTVHYVRRG LWEKISAKGP TTAPLHLLVL LFQDQNYGLH
     YEYTIPSDPL PENQSSKAPE PLFMWTHTSW EDCDATCGGG ERKTTVSCTK IMSKNISIVD
     NEKCKYLTKP EPQIRKCNEQ PCQTRWMMTE WTPCSRTCGK GMQSRQVACT QQLSNGTLIR
     ARERDCIGPK PASAQRCEGQ DCMTVWEAGV WSECSVKCGK GIRHRTVRCT NPRKKCVLST
     RPREAEDCED YSKCYVWRMG DWSKCSITCG KGMQSRVIQC MHKITGRHGN ECFSSEKPAA
     YRPCHLQPCN EKINVNTITS PRLAALTFKC LGDQWPVYCR VIREKNLCQD MRWYQRCCET
     CRDFYAQKLQ QKS
//