ID A0A1W2PRT6_HUMAN Unreviewed; 383 AA. AC A0A1W2PRT6; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 05-DEC-2018, entry version 10. DE SubName: Full=Calcium-activated potassium channel subunit alpha-1 {ECO:0000313|Ensembl:ENSP00000492837}; DE Flags: Fragment; GN Name=KCNMA1 {ECO:0000313|Ensembl:ENSP00000492837}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000492837, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000492837, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000492837} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2017) to UniProtKB. CC -!- SIMILARITY: Belongs to the potassium channel family. CC {ECO:0000256|SAAS:SAAS00692852}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC011439; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC021032; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC067745; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL157833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL607069; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL627447; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL731556; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL731560; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL731575; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A1W2PRT6; -. DR Ensembl; ENST00000638249; ENSP00000492837; ENSG00000156113. DR HGNC; HGNC:6284; KCNMA1. DR OpenTargets; ENSG00000156113; -. DR GeneTree; ENSGT00940000154935; -. DR ChiTaRS; KCNMA1; human. DR Proteomes; UP000005640; Chromosome 10. DR ExpressionAtlas; A0A1W2PRT6; baseline and differential. DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. DR GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro. DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW. DR Gene3D; 1.20.120.350; -; 1. DR InterPro; IPR024939; Ca-act_K_channel_Slo-1. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR028325; VG_K_chnl. DR InterPro; IPR027359; Volt_channel_dom_sf. DR PANTHER; PTHR10027:SF28; PTHR10027:SF28; 1. DR Pfam; PF00520; Ion_trans; 1. DR PRINTS; PR00169; KCHANNEL. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Ion channel {ECO:0000256|SAAS:SAAS00417246, KW ECO:0000256|SAAS:SAAS00984201}; KW Ion transport {ECO:0000256|SAAS:SAAS00417246, KW ECO:0000256|SAAS:SAAS00984201}; KW Membrane {ECO:0000256|SAAS:SAAS00084701, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|SAAS:SAAS00417246}; KW Potassium channel {ECO:0000256|SAAS:SAAS00417246}; KW Potassium transport {ECO:0000256|SAAS:SAAS00417246}; KW Proteomics identification {ECO:0000213|MaxQB:A0A1W2PRT6, KW ECO:0000213|PeptideAtlas:A0A1W2PRT6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00084701, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00084701, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|SAAS:SAAS00417246, KW ECO:0000256|SAAS:SAAS00984201}; KW Voltage-gated channel {ECO:0000256|SAAS:SAAS00984201}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 383 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012619390. FT TRANSMEM 77 95 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 115 133 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 198 219 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 234 253 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 265 283 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 80 290 Ion_trans. {ECO:0000259|Pfam:PF00520}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000492837}. SQ SEQUENCE 383 AA; 43483 MW; 3985954AD00646CA CRC64; XIILLWRTLK YLWTVCCHCG GKTKEAQKIN NGSSQADGTL KPVDEKEEAV AAEVGWMTSV KDWAGVMISA QTLTGRVLVV LVFALSIGAL VIYFIDSSNP IESCQNFYKD FTLQIDMAFN VFFLLYFGLR FIAANDKLWF WLEVNSVVDF FTVPPVFVSV YLNRSWLGLR FLRALRLIQF SEILQFLNIL KTSNSIKLVN LLSIFISTWL TAAGFIHLVE NSGDPWENFQ NNQALTYWEC VYLLMVTMST VGYGDVYAKT TLGRLFMVFF ILGGLAMFAS YVPEIIELIG NRKKYGGSYS AVSGRKHIVV CGHITLESVS NFLKDFLHKD RDDVNVEIVF LHKLRKTHGR NTTWKESQMK CTQNISPVPS WVCPSLLFVS CVL //