ID   A0A1W2PRS1_HUMAN        Unreviewed;       519 AA.
AC   A0A1W2PRS1;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   16-JAN-2019, entry version 11.
DE   SubName: Full=Lysosome membrane protein 2 {ECO:0000313|Ensembl:ENSP00000492737};
DE   Flags: Fragment;
GN   Name=SCARB2 {ECO:0000313|Ensembl:ENSP00000492737};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000492737, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000492737, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [5] {ECO:0000313|Ensembl:ENSP00000492737}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CD36 family.
CC       {ECO:0000256|SAAS:SAAS00579224}.
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DR   EMBL; AC034139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC110795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; A0A1W2PRS1; -.
DR   PeptideAtlas; A0A1W2PRS1; -.
DR   Ensembl; ENST00000640634; ENSP00000492737; ENSG00000138760.
DR   HGNC; HGNC:1665; SCARB2.
DR   OpenTargets; ENSG00000138760; -.
DR   GeneTree; ENSGT00940000153372; -.
DR   ChiTaRS; SCARB2; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   ExpressionAtlas; A0A1W2PRS1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005764; C:lysosome; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   InterPro; IPR002159; CD36_fam.
DR   InterPro; IPR005429; LimpII.
DR   PANTHER; PTHR11923; PTHR11923; 2.
DR   Pfam; PF01130; CD36; 1.
DR   PRINTS; PR01609; CD36FAMILY.
DR   PRINTS; PR01611; LIMPII.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00106193, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A1W2PRS1,
KW   ECO:0000213|MaxQB:A0A1W2PRS1, ECO:0000213|PeptideAtlas:A0A1W2PRS1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00106193,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00106193,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    519       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012958432.
FT   TRANSMEM    479    499       Helical. {ECO:0000256|SAM:Phobius}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000492737}.
SQ   SEQUENCE   519 AA;  58160 MW;  8BD6A070BFF5CB3E CRC64;
     XAGTLSLLLL VTSVTLLVAR VFQKAVDQSI EKKIVLRNGT EAFDSWEKPP LPVYTQFYFF
     NVTNPEEILR GETPRVEEVG PYTYRELRNK ANIQFGDNGT TISAVSNKAY VFERDQSVGD
     PKIDLIRTLN IPVLTGSCSV AQAGVQSVAP SQLTEASTSW APGILLCRPG TPGVNHCSWA
     GPTVIEWSQV HFLREIIEAM LKAYQQKLFV THTVDELLWG YKDEILSLIH VFRPDISPYF
     GLFYEKNGTN DGDYVFLTGE DSYLNFTKIV EWNGKTSLDW WITDKCNMIN GTDGDSFHPL
     ITKDEVLYVF PSDFCRSVYI TFSDYESVQG LPAFRYKVPA EILANTSDNA GFCIPEGNCL
     GSGVLNVSIC KNGAPIIMSF PHFYQADERF VSAIEGMHPN QEDHETFVDI NPLTGIILKA
     AKRFQINIYV KKLDDFVETG DIRTMVFPVM YLNESVHIDK ETASRLKSMI NTTLIITNIP
     YIIMALGVFF GLVFTWLACK GQGSMDEGTA DERAPLIRT
//