ID A0A1W2PRN4_HUMAN Unreviewed; 453 AA. AC A0A1W2PRN4; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 05-DEC-2018, entry version 10. DE SubName: Full=Gamma-aminobutyric acid receptor subunit gamma-2 {ECO:0000313|Ensembl:ENSP00000492581}; GN Name=GABRG2 {ECO:0000313|Ensembl:ENSP00000492581}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000492581, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000492581, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000492581} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2017) to UniProtKB. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) CC family. {ECO:0000256|RuleBase:RU000687, CC ECO:0000256|SAAS:SAAS00978283}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC008611; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091926; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091984; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A1W2PRN4; -. DR Ensembl; ENST00000639683; ENSP00000492581; ENSG00000113327. DR HGNC; HGNC:4087; GABRG2. DR OpenTargets; ENSG00000113327; -. DR GeneTree; ENSGT00940000156685; -. DR ChiTaRS; GABRG2; human. DR Proteomes; UP000005640; Chromosome 5. DR ExpressionAtlas; A0A1W2PRN4; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro. DR GO; GO:0006821; P:chloride transport; IEA:InterPro. DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006028; GABAA/Glycine_rcpt. DR InterPro; IPR005437; GABBAg_rcpt. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR PANTHER; PTHR18945; PTHR18945; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00253; GABAARECEPTR. DR PRINTS; PR01620; GABAARGAMMA. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 1: Evidence at protein level; KW Cell membrane {ECO:0000256|SAAS:SAAS00081375}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00766067}; KW Ion channel {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}; KW Ion transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}; KW Membrane {ECO:0000256|SAAS:SAAS00081375, KW ECO:0000256|SAAS:SAAS00978768, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A1W2PRN4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 453 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012777476. FT TRANSMEM 250 273 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 285 304 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 316 338 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 433 452 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 47 250 Neur_chan_LBD. FT {ECO:0000259|Pfam:PF02931}. FT DOMAIN 257 354 Neur_chan_memb. FT {ECO:0000259|Pfam:PF02932}. SQ SEQUENCE 453 AA; 52813 MW; 31BE7C3E8B3F596A CRC64; MTVWILLLLS LYPGFTSQKS DDDYEDYASN KTWVLTPKVP EGDVTVILNN LLEGYDNKLR PDIGVKPTLI HTDMYVNSIG PVNAINMEYT IDIFFAQTWY DRRLKFNSTI KVLRLNSNMV GKIWIPDTFF RNSKKADAHW ITTPNRMLRI WNDGRVLYTL RLTIDAECQL QLHNFPMDEH SCPLEFSSYG YPREEIVYQW KRSSVEVGDT RSWRLYQFSF VGLRNTTEVV KTTSGDYVVM SVYFDLSRRM GYFTIQTYIP CTLIVVLSWV SFWINKDAVP ARTSLGITTV LTMTTLSTIA RKSLPKVSYV TAMDLFVSVC FIFVFSALVE YGTLHYFVSN RKPSKDKDKK KKNPLLRMFS FKAPTIDIRP RSATIQMNNA THLQERDEEY GYECLDGKDC ASFFCCFEDC RTGAWRHGRI HIRIAKMDSY ARIFFPTAFC LFNLVYWVSY LYL //