ID A0A1W2PR49_HUMAN Unreviewed; 445 AA. AC A0A1W2PR49; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 05-DEC-2018, entry version 10. DE SubName: Full=Gamma-aminobutyric acid receptor subunit gamma-2 {ECO:0000313|Ensembl:ENSP00000492096}; GN Name=GABRG2 {ECO:0000313|Ensembl:ENSP00000492096}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000492096, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000492096, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000492096} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2017) to UniProtKB. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) CC family. {ECO:0000256|RuleBase:RU000687, CC ECO:0000256|SAAS:SAAS00978283}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC008611; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091926; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091984; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000639975; ENSP00000492096; ENSG00000113327. DR HGNC; HGNC:4087; GABRG2. DR OpenTargets; ENSG00000113327; -. DR GeneTree; ENSGT00940000156685; -. DR ChiTaRS; GABRG2; human. DR Proteomes; UP000005640; Chromosome 5. DR ExpressionAtlas; A0A1W2PR49; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro. DR GO; GO:0006821; P:chloride transport; IEA:InterPro. DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006028; GABAA/Glycine_rcpt. DR InterPro; IPR005437; GABBAg_rcpt. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR PANTHER; PTHR18945; PTHR18945; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00253; GABAARECEPTR. DR PRINTS; PR01620; GABAARGAMMA. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 1: Evidence at protein level; KW Cell membrane {ECO:0000256|SAAS:SAAS00081375}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00766067}; KW Ion channel {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}; KW Ion transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}; KW Membrane {ECO:0000256|SAAS:SAAS00081375, KW ECO:0000256|SAAS:SAAS00978768, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A1W2PR49}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 445 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012303459. FT TRANSMEM 250 273 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 285 304 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 316 338 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 425 444 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 47 250 Neur_chan_LBD. FT {ECO:0000259|Pfam:PF02931}. FT DOMAIN 257 378 Neur_chan_memb. FT {ECO:0000259|Pfam:PF02932}. SQ SEQUENCE 445 AA; 51790 MW; 554177660200D0AC CRC64; MTVWILLLLS LYPGFTSQKS DDDYEDYASN KTWVLTPKVP EGDVTVILNN LLEGYDNKLR PDIGVKPTLI HTDMYVNSIG PVNAINMEYT IDIFFAQTWY DRRLKFNSTI KVLRLNSNMV GKIWIPDTFF RNSKKADAHW ITTPNRMLRI WNDGRVLYTL RLTIDAECQL QLHNFPMDEH SCPLEFSSYG YPREEIVYQW KRSSVEVGDT RSWRLYQFSF VGLRNTTEVV KTTSGDYVVM SVYFDLSRRM GYFTIQTYIP CTLIVVLSWV SFWINKDAVP ARTSLGITTV LTMTTLSTIA RKSLPKVSYV TAMDLFVSVC FIFVFSALVE YGTLHYFVSN RKPSKDKDKK KKNPAPTIDI RPRSATIQMN NATHLQERDE EYGYECLDGK DCASFFCCFE DCRTGAWRHG RIHIRIAKMD SYARIFFPTA FCLFNLVYWV SYLYL //