ID   A0A1W2PR41_HUMAN        Unreviewed;       263 AA.
AC   A0A1W2PR41;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   05-DEC-2018, entry version 8.
DE   SubName: Full=Tumor necrosis factor receptor superfamily member 11A {ECO:0000313|Ensembl:ENSP00000492422};
GN   Name=TNFRSF11A {ECO:0000313|Ensembl:ENSP00000492422};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000492422, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000492422, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000492422}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR   EMBL; AC100843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; A0A1W2PR41; -.
DR   Ensembl; ENST00000639222; ENSP00000492422; ENSG00000141655.
DR   HGNC; HGNC:11908; TNFRSF11A.
DR   OpenTargets; ENSG00000141655; -.
DR   GeneTree; ENSGT00940000161211; -.
DR   ChiTaRS; TNFRSF11A; human.
DR   Proteomes; UP000005640; Chromosome 18.
DR   ExpressionAtlas; A0A1W2PR41; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd13411; TNFRSF11A; 1.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR022323; TNFR_11.
DR   InterPro; IPR022361; TNFR_11A.
DR   InterPro; IPR034040; TNFRSF11A_N.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PRINTS; PR01961; TNFACTORR11.
DR   PRINTS; PR01974; TNFACTORR11A.
DR   SMART; SM00208; TNFR; 4.
DR   PROSITE; PS00652; TNFR_NGFR_1; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A1W2PR41};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    263       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013094282.
FT   TRANSMEM    209    235       Helical. {ECO:0000256|SAM:Phobius}.
FT   REPEAT       33     68       TNFR-Cys. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00206}.
FT   DOMAIN       33     68       TNFR-Cys. {ECO:0000259|PROSITE:PS50050}.
FT   DISULFID     47     60       {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT   DISULFID     50     68       {ECO:0000256|PROSITE-ProRule:PRU00206}.
SQ   SEQUENCE   263 AA;  28920 MW;  B5C72E8DEFA676C2 CRC64;
     MAPRARRRRP LFALLLLCAL LARLQVALQI APPCTSEKHY EHLGRCCNKC EPGKYMSSKC
     TTTSDSVCLP CGPDEYLDSW NEEDKCLLHK VCDTGKALVA VVAGNSTTPR RCACTAGYHW
     SQDCECCRRN TECAPGLGAQ HPLQLNKDTV CKPCLAGYFS DAFSSTDKCR PWTNCTFLGK
     RVEHHGTEKS DAVCSSSLPA RKPPNEPHVY LPGLIILLLF ASVALVAAII FGVCYRKKGK
     ALTANLWHWI NEACGRLSGD KES
//