ID A0A1W2PQX7_HUMAN Unreviewed; 441 AA. AC A0A1W2PQX7; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 16-JAN-2019, entry version 11. DE SubName: Full=Multidrug resistance-associated protein 6 {ECO:0000313|Ensembl:ENSP00000492197}; GN Name=ABCC6 {ECO:0000313|Ensembl:ENSP00000492197}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000492197, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000492197, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., RA Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000313|Ensembl:ENSP00000492197} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2017) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC136624; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; A0A1W2PQX7; -. DR PeptideAtlas; A0A1W2PQX7; -. DR Ensembl; ENST00000640696; ENSP00000492197; ENSG00000091262. DR HGNC; HGNC:57; ABCC6. DR OpenTargets; ENSG00000091262; -. DR GeneTree; ENSGT00940000157145; -. DR ChiTaRS; ABCC6; human. DR Proteomes; UP000005640; Chromosome 16. DR ExpressionAtlas; A0A1W2PQX7; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. DR Gene3D; 1.20.1560.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR011527; ABC1_TM_dom. DR InterPro; IPR036640; ABC1_TM_sf. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR017871; ABC_transporter_CS. DR InterPro; IPR030239; ABCC6. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR24223:SF339; PTHR24223:SF339; 2. DR Pfam; PF00664; ABC_membrane; 1. DR Pfam; PF00005; ABC_tran; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR SUPFAM; SSF90123; SSF90123; 1. DR PROSITE; PS50929; ABC_TM1F; 1. DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00434}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00434}; KW Proteomics identification {ECO:0000213|MaxQB:A0A1W2PQX7, KW ECO:0000213|PeptideAtlas:A0A1W2PQX7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 441 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5010743667. FT TRANSMEM 71 94 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 4 79 ABC transmembrane type-1. FT {ECO:0000259|PROSITE:PS50929}. FT DOMAIN 203 437 ABC transporter. FT {ECO:0000259|PROSITE:PS50893}. FT NP_BIND 237 244 ATP. {ECO:0000256|PROSITE- FT ProRule:PRU00434}. SQ SEQUENCE 441 AA; 47942 MW; 05290B36D594EF03 CRC64; PSPAIGLFAS MAAVLLGGAR ASRLLFQRLL WDVVRSPISF FERTPIGHLL NRFSKETDTV DVDIPDKLRS LLMYAFGLLE VSLVVAVATP LPLWPSCHCF SSTLGFRWLA ANVELLGNGL VFAAATCAVL SKAHLSAGLV GFSVSAALQV TQTLQWVVRN WTDLENSIVS VERMQDYAWT PKEAPWRLPT CAAQPPWPQG GQIEFRDFGL RYRPELPLAV QGVSFKIHAG EKVGIVGRTG AGKSSLASGL LRLQEAAEGG IWIDGVPIAH VGLHTLRSRI SIIPQDPILF PGSLRMNLDL LQEHSDEAIW AALETVQLKA LVASLPGQLQ YKCADRGEDL SVGQKQLLCL ARALLRKTQI LILDEATAAV DPGTELQMQA MLGSWFAQCT VLLIAHRLRS VMDCARVLVM DKGQVAESGS PAQLLAQKGL FYRLAQESGL V //