ID A0A1W2PQX1_HUMAN Unreviewed; 397 AA. AC A0A1W2PQX1; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 05-DEC-2018, entry version 10. DE SubName: Full=Gamma-aminobutyric acid receptor subunit gamma-2 {ECO:0000313|Ensembl:ENSP00000491958}; DE Flags: Fragment; GN Name=GABRG2 {ECO:0000313|Ensembl:ENSP00000491958}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000491958, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000491958, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000491958} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2017) to UniProtKB. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) CC family. {ECO:0000256|RuleBase:RU000687, CC ECO:0000256|SAAS:SAAS00978283}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC008611; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091926; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091984; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A1W2PQX1; -. DR Ensembl; ENST00000639278; ENSP00000491958; ENSG00000113327. DR HGNC; HGNC:4087; GABRG2. DR OpenTargets; ENSG00000113327; -. DR GeneTree; ENSGT00940000156685; -. DR ChiTaRS; GABRG2; human. DR Proteomes; UP000005640; Chromosome 5. DR ExpressionAtlas; A0A1W2PQX1; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro. DR GO; GO:0006821; P:chloride transport; IEA:InterPro. DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006028; GABAA/Glycine_rcpt. DR InterPro; IPR005437; GABBAg_rcpt. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR PANTHER; PTHR18945; PTHR18945; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00253; GABAARECEPTR. DR PRINTS; PR01620; GABAARGAMMA. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 1: Evidence at protein level; KW Cell membrane {ECO:0000256|SAAS:SAAS00081375}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Ion channel {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}; KW Ion transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}; KW Membrane {ECO:0000256|SAAS:SAAS00081375, KW ECO:0000256|SAAS:SAAS00978768, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A1W2PQX1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457629}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 397 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012958439. FT TRANSMEM 248 272 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 313 336 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 45 248 Neur_chan_LBD. FT {ECO:0000259|Pfam:PF02931}. FT DOMAIN 255 354 Neur_chan_memb. FT {ECO:0000259|Pfam:PF02932}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000491958}. SQ SEQUENCE 397 AA; 45661 MW; 0BC22BA0DC9A8784 CRC64; VWILLLLSLY PGFTSQKSDD DYEDYASNKT WVLTPKVPEG DVTVILNNLL EGYDNKLRPD IGVKPTLIHT DMYVNSIGPV NAINMEYTID IFFAQTWYDR RLKFNSTIKV LRLNSNMVGK IWIPDTFFRN SKKADAHWIT TPNRMLRIWN DGRVLYTLRL TIDAECQLQL HNFPMDEHSC PLEFSSYGYP REEIVYQWKR SSVEVGDTRS WRLYQFSFVG LRNTTEVVKT TSGDYVVMSV YFDLSRRMGY FTIQTYIPCT LIVVLSWVSF WINKDAVPAR TSLGITTVLT MTTLSTIARK SLPKVSYVTA MDLFVSVCFI FVFSALVEYG TLHYFVSNRK PSKDKDKKKK NPKVVLLRVG ILPASYNKDM RTGFQTSSDE SFGKSPLALS VSYAIAE //