ID   A0A1W2PNX8_HUMAN        Unreviewed;      1084 AA.
AC   A0A1W2PNX8;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   16-JAN-2019, entry version 11.
DE   SubName: Full=Protein unc-45 homolog A {ECO:0000313|Ensembl:ENSP00000491150};
GN   Name=UNC45A {ECO:0000313|Ensembl:ENSP00000491150};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000491150, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000491150, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000213|PubMed:19608861}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA   Walther T.C., Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [3] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [6] {ECO:0000313|Ensembl:ENSP00000491150}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2017) to UniProtKB.
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DR   EMBL; AC068831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; A0A1W2PNX8; -.
DR   PeptideAtlas; A0A1W2PNX8; -.
DR   Ensembl; ENST00000639885; ENSP00000491150; ENSG00000140553.
DR   HGNC; HGNC:30594; UNC45A.
DR   OpenTargets; ENSG00000140553; -.
DR   GeneTree; ENSGT00940000159320; -.
DR   ChiTaRS; UNC45A; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   ExpressionAtlas; A0A1W2PNX8; baseline and differential.
DR   Gene3D; 1.25.10.10; -; 2.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013026; TPR-contain_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR024660; UCS_central_dom.
DR   Pfam; PF13181; TPR_8; 1.
DR   Pfam; PF11701; UNC45-central; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A1W2PNX8,
KW   ECO:0000213|MaxQB:A0A1W2PNX8, ECO:0000213|PeptideAtlas:A0A1W2PNX8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31   1084       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012709684.
FT   DOMAIN      161    265       TPR_REGION.
FT                                {ECO:0000259|PROSITE:PS50293}.
FT   REPEAT      161    194       TPR. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00339}.
FT   REPEAT      198    231       TPR. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00339}.
FT   REPEAT      232    265       TPR. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00339}.
SQ   SEQUENCE   1084 AA;  118395 MW;  79776972610C9330 CRC64;
     MGIQRRSGPL LTGLSVGLLL LFSWVTLVQP TSLSALVHHP HLCQTTRDVH GRHYPGFFCP
     RLSDSPEEAY CCHLQAAGGS CCTRAEFEAL YQVNLSALPP PPILRGPGPL LVLGLYNLLV
     VTLMTVDLVH FCCGRGRSLG WSHRRPPSGS SAASSLQASS VEQLRKEGNE LFKCGDYGGA
     LAAYTQALGL DATPQDQAVL HRNRAACHLK LEDYDKAETE ASKAIEKDGG DVKALYRRSQ
     ALEKLGRLDQ AVLDLQRCVS LEPKNKVFQE ALRNIGGQIQ EKVRYMSSTD AKVEQMFQIL
     LDPEEKGTEK KQKASQNLVV LAREDAGAEK IFRSNGVQLL QRLLDMGETD LMLAALRTLV
     GICSEHQSRT VATLSILGTR RVVSILGVES QAVSLAACHL LQVMFDALKE GVKKGFRGKE
     GAIIVDPARE LKVLISNLLD LLTEVGVSGQ GRDNALTLLI KAVPRKSLKD PNNSLTLWVI
     DQGLKKILEV GGSLQDPPGE LAVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCENYIK
     SWFEGQGLAG KLRAIQTVSC LLQGPCDAGN RALELSGVME SVIALCASEQ EEEQLVAVEA
     LIHAAGKAKR ASFITANGVS LLKDLYKCSE KDSIRIRALV GLCKLGSAGG TDFSMKQFAE
     GSTLKLAKQC RKWLCNDQID AGTRRWAVEG LAYLTFDADV KEEFVEDAAA LKALFQLSRL
     EERSVLFAVA SALVNCTNSY DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVRARVKKLL
     AAGVVSAMVC MVKTESPVLT SSCRELLSRV FLALVEEVED RGTVVAQGGG RALIPLALEG
     TDVGQTKAAQ ALAKLTITSN PEMTFPGERI YEVVRPLVSL LHLNCSGLQN FEALMALTNL
     AGISERLRQK ILKEKAVPMI EGYMFEEHEM IRRAATECMC NLAMSKEVQD LFEAQGNDRL
     KLLVLYSGED DELLQRAAAG GLAMLTSMRP TLCSRIPQVT THWLEILQAL LLSSNQELQH
     RGAVVVLNMV EASREIASTL MESEMMEILS VLAKGDHSPV TRAAAACLDK AVEYGLIQPN
     QDGE
//