ID A0A1W2PNW4_HUMAN Unreviewed; 665 AA. AC A0A1W2PNW4; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 16-JAN-2019, entry version 13. DE SubName: Full=Vascular endothelial growth factor receptor 1 {ECO:0000313|Ensembl:ENSP00000491097}; GN Name=FLT1 {ECO:0000313|Ensembl:ENSP00000491097}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000491097, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000491097, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057823; DOI=10.1038/nature02379; RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R., RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.; RT "The DNA sequence and analysis of human chromosome 13."; RL Nature 428:522-528(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000491097} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2017) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL138712; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL139005; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; A0A1W2PNW4; -. DR PeptideAtlas; A0A1W2PNW4; -. DR Ensembl; ENST00000639477; ENSP00000491097; ENSG00000102755. DR HGNC; HGNC:3763; FLT1. DR OpenTargets; ENSG00000102755; -. DR GeneTree; ENSGT00940000158713; -. DR ChiTaRS; FLT1; human. DR Proteomes; UP000005640; Chromosome 13. DR ExpressionAtlas; A0A1W2PNW4; baseline and differential. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro. DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 6. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR009135; VEGFR1_rcpt. DR Pfam; PF07679; I-set; 1. DR Pfam; PF00047; ig; 1. DR PRINTS; PR01833; VEGFRECEPTR1. DR SMART; SM00409; IG; 6. DR SMART; SM00408; IGc2; 4. DR SMART; SM00406; IGv; 2. DR SUPFAM; SSF48726; SSF48726; 6. DR PROSITE; PS50835; IG_LIKE; 5. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Proteomics identification {ECO:0000213|MaxQB:A0A1W2PNW4, KW ECO:0000213|PeptideAtlas:A0A1W2PNW4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 665 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012031947. FT DOMAIN 32 107 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 230 327 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 349 404 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 428 553 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 556 654 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 665 AA; 74925 MW; BC9F3BE1436D987B CRC64; MVSYWDTGVL LCALLSCLLL TGSSSGSKLK DPELSLKGTQ HIMQAGQTLH LQCRGEAAHK WSLPEMVSKE SERLSITKSA CGRNGKQFCS TLTLNTAQAN HTGFYSCKYL AVPTSKKKET ESAIYIFISD TGRPFVEMYS EIPEIIHMTE GRELVIPCRV TSPNITVTLK KFPLDTLIPD GKRIIWDSRK GFIISNATYK EIGLLTCEAT VNGHLYKTNY LTHRQTNTII DVQISTPRPV KLLRGHTLVL NCTATTPLNT RVQMTWSYPD EKNKRASVRR RIDQSNSHAN IFYSVLTIDK MQNKDKGLYT CRVRSGPSFK SVNTSVHIYD KAFITVKHRK QQVLETVAGK RSYRLSMKVK AFPSPEVVWL KDGLPATEKS ARYLTRGYSL IIKDVTEEDA GNYTILLSIK QSNVFKNLTA TLIVNVKPQI YEKAVSSFPD PALYPLGSRQ ILTCTAYGIP QPTIKWFWHP CNHNHSEARC DFCSNNEESF ILDADSNMGN RIESITQRMA IIEGKNKMAS TLVVADSRIS GIYICIASNK VGTVGRNISF YITDVPNGFH VNLEKMPTEG EDLKLSCTVN KFLYRDVTWI LLRTVNNRTM HYSISKQKMA ITKEHSITLN LTIMNVSLQD SGTYACRARN VYTGEEILQK KEITIRGSEE MLLPK //