ID A0A1W2PN81_HUMAN Unreviewed; 502 AA. AC A0A1W2PN81; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 16-JAN-2019, entry version 11. DE SubName: Full=Neuronal acetylcholine receptor subunit alpha-7 {ECO:0000313|Ensembl:ENSP00000488147}; GN Name=CHRNA7 {ECO:0000313|Ensembl:ENSP00000488147}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000488147, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000488147, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., RA Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., RA Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human RT chromosome 15."; RL Nature 440:671-675(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000488147} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2017) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000494974} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell CC membrane {ECO:0000256|SAAS:SAAS00569352}; Multi-pass membrane CC protein {ECO:0000256|SAAS:SAAS00569352}. Cell membrane CC {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00569391}. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) CC family. {ECO:0000256|RuleBase:RU000687, CC ECO:0000256|SAAS:SAAS00978283}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC254952; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC254957; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR BioMuta; ENSG00000282088; -. DR jPOST; A0A1W2PN81; -. DR Ensembl; ENST00000632335; ENSP00000488147; ENSG00000282088. DR Ensembl; ENST00000645153; ENSP00000494974; ENSG00000282088. DR Proteomes; UP000005640; Chromosome 15. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt. DR PANTHER; PTHR18945; PTHR18945; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00254; NICOTINICR. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 3: Inferred from homology; KW Cell junction {ECO:0000256|SAAS:SAAS00103558}; KW Cell membrane {ECO:0000256|SAAS:SAAS00081553}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00103544}; KW Ion channel {ECO:0000256|SAAS:SAAS00032596}; KW Ion transport {ECO:0000256|SAAS:SAAS00032596}; KW Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00032596}; KW Membrane {ECO:0000256|SAAS:SAAS00081553, KW ECO:0000256|SAAS:SAAS00103558, ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00103558}; KW Receptor {ECO:0000256|SAAS:SAAS00079193}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Synapse {ECO:0000256|SAAS:SAAS00103558}; KW Transmembrane {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00032596}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 502 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012642111. FT TRANSMEM 231 255 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 262 280 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 292 317 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 470 490 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 27 230 Neur_chan_LBD. FT {ECO:0000259|Pfam:PF02931}. FT DOMAIN 237 487 Neur_chan_memb. FT {ECO:0000259|Pfam:PF02932}. SQ SEQUENCE 502 AA; 56491 MW; DF4F6B8CFE0CB3D3 CRC64; MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP LTVYFSLSLL QIMDVDQKRQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD FA //