ID A0A1U9X989_HUMAN Unreviewed; 2002 AA. AC A0A1U9X989; A0A140T920; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 30-AUG-2017, sequence version 2. DT 16-JAN-2019, entry version 11. DE SubName: Full=NOTCH4 {ECO:0000313|EMBL:AQY77343.2}; DE SubName: Full=Neurogenic locus notch homolog protein 4 {ECO:0000313|Ensembl:ENSP00000389207}; GN Name=NOTCH4 {ECO:0000313|Ensembl:ENSP00000389207}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AQY77343.2}; RN [1] {ECO:0000313|Ensembl:ENSP00000389207, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000389207} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. RN [3] {ECO:0000313|EMBL:AQY77343.2} RP NUCLEOTIDE SEQUENCE. RA Norman P.J., Norberg S.J., Nemat-Gorgani N., Ronaghi M., Parham P.; RT "CDS alleles of MHC region genes derived from homozygous RT individuals."; RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; BX927239; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KY500852; AQY77320.2; -; Genomic_DNA. DR EMBL; KY500867; AQY77335.2; -; Genomic_DNA. DR EMBL; KY500868; AQY77336.2; -; Genomic_DNA. DR EMBL; KY500875; AQY77343.2; -; Genomic_DNA. DR UniGene; Hs.436100; -. DR jPOST; A0A1U9X989; -. DR Ensembl; ENST00000454571; ENSP00000389207; ENSG00000232339. DR HGNC; HGNC:7884; NOTCH4. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro. DR GO; GO:0030154; P:cell differentiation; IEA:InterPro. DR GO; GO:0007275; P:multicellular organism development; IEA:InterPro. DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro. DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro. DR CDD; cd00204; ANK; 2. DR Gene3D; 1.25.40.20; -; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR020683; Ankyrin_rpt-contain_dom. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR008297; Notch. DR InterPro; IPR035993; Notch-like_dom_sf. DR InterPro; IPR022355; Notch_4. DR InterPro; IPR000800; Notch_dom. DR InterPro; IPR010660; Notch_NOD_dom. DR InterPro; IPR011656; Notch_NODP_dom. DR Pfam; PF00023; Ank; 1. DR Pfam; PF12796; Ank_2; 1. DR Pfam; PF00008; EGF; 12. DR Pfam; PF07645; EGF_CA; 5. DR Pfam; PF12661; hEGF; 3. DR Pfam; PF06816; NOD; 1. DR Pfam; PF07684; NODP; 1. DR Pfam; PF00066; Notch; 3. DR PIRSF; PIRSF002279; Notch; 5. DR PRINTS; PR01452; LNOTCHREPEAT. DR PRINTS; PR01987; NOTCH4. DR SMART; SM00248; ANK; 5. DR SMART; SM00181; EGF; 29. DR SMART; SM00179; EGF_CA; 22. DR SMART; SM00004; NL; 3. DR SMART; SM01338; NOD; 1. DR SMART; SM01339; NODP; 1. DR SUPFAM; SSF48403; SSF48403; 1. DR SUPFAM; SSF57184; SSF57184; 4. DR SUPFAM; SSF90193; SSF90193; 2. DR PROSITE; PS50297; ANK_REP_REGION; 1. DR PROSITE; PS50088; ANK_REPEAT; 5. DR PROSITE; PS00010; ASX_HYDROXYL; 11. DR PROSITE; PS00022; EGF_1; 27. DR PROSITE; PS01186; EGF_2; 20. DR PROSITE; PS50026; EGF_3; 28. DR PROSITE; PS01187; EGF_CA; 3. DR PROSITE; PS50258; LNR; 3. PE 1: Evidence at protein level; KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}; KW Calcium {ECO:0000256|PIRSR:PIRSR002279-1}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002279-2, ECO:0000256|PROSITE- KW ProRule:PRU00076, ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1}; KW Proteomics identification {ECO:0000213|MaxQB:A0A1U9X989, KW ECO:0000213|PeptideAtlas:A0A1U9X989}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 2002 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014546735. FT DOMAIN 23 62 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 63 114 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 117 154 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 155 191 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 193 231 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 233 273 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 275 311 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 313 352 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 354 390 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 391 429 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 431 472 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 474 510 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 512 548 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 550 586 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 588 624 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 625 658 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 690 726 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 728 764 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 766 802 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 805 841 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 843 879 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 892 927 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 929 965 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 967 1003 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1005 1043 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1045 1084 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1086 1125 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1129 1170 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1169 1212 LNR. {ECO:0000259|PROSITE:PS50258}. FT DOMAIN 1213 1249 LNR. {ECO:0000259|PROSITE:PS50258}. FT DOMAIN 1250 1293 LNR. {ECO:0000259|PROSITE:PS50258}. FT DOMAIN 1585 1822 ANK_REP_REGION. FT {ECO:0000259|PROSITE:PS50297}. FT REPEAT 1632 1664 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1665 1687 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1699 1731 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1732 1764 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1765 1797 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT METAL 454 454 Calcium 1; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 457 457 Calcium 1; via amide nitrogen. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 474 474 Calcium 2. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 477 477 Calcium 2. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 491 491 Calcium 2. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 513 513 Calcium 3; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 515 515 Calcium 3. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 529 529 Calcium 3. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT DISULFID 52 61 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 104 113 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 144 153 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 181 190 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 221 230 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 263 272 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 301 310 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 342 351 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 380 389 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 400 417 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 419 428 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 435 451 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 445 460 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 462 471 {ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 478 489 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 483 498 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 500 509 {ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 516 527 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 521 536 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 538 547 {ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 576 585 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 614 623 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 716 725 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 754 763 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 792 801 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 831 840 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 869 878 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 896 906 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 917 926 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 955 964 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 993 1002 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1014 1031 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1033 1042 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1074 1083 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1115 1124 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1160 1169 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 2002 AA; 209509 MW; C4BF06784CDDC401 CRC64; MQPPSLLLLL LLLLLCVSVV RPRGLLCGSF PEPCANGGTC LSLSLGQGTC QCAPGFLGET CQFPDPCQNA QLCQNGGSCQ ALLPAPLGLP SSPSPLTPSF LCTCLPGFTG ERCQAQLEDP CPPSFCSKRG RCHIQASGRP QCSCMPGWTG EQCQLRDFCS ANPCVNGGVC LATYPQIQCH CPPGFEGHAC ERDVNECFQD PGPCPKGTSC HNTLGSFQCL CPVGQEGPRC ELRAGPCPPR GCSNGGTCQL MPEKDSTFHL CLCPPGFIGP DCEVNPDNCV SHQCQNGGTC QDGLDTYTCL CPETWTGWDC SEDVDECETQ GPPHCRNGGT CQNSAGSFHC VCVSGWGGTS CEENLDDCIA ATCAPGSTCI DRVGSFSCLC PPGRTGLLCH LEDMCLSQPC HGDAQCSTNP LTGSTLCLCQ PGYSGPTCHQ DLDECLMAQQ GPSPCEHGGS CLNTPGSFNC LCPPGYTGSR CEADHNECLS QPCHPGSTCL DLLATFHCLC PPGLEGQLCE VETNECASAP CLNHADCHDL LNGFQCICLP GFSGTRCEED IDECRSSPCA NGGQCQDQPG AFHCKCLPGF EGPRCQTEVD ECLSDPCPVG ASCLDLPGAF FCLCPSGFTG QLCEVPLCAP NLCQPKQICK DQKDKANCLC PDGSPGCAPP EDNCTCHHGH CQRSSCVCDV GWTGPECEAE LGGCISAPCA HGGTCYPQPS GYNCTCPTGY TGPTCSEEMT ACHSGPCLNG GSCNPSPGGY YCTCPPSHTG PQCQTSTDYC VSAPCFNGGT CVNRPGTFSC LCAMGFQGPR CEGKLRPSCA DSPCRNRATC QDSPQGPRCL CPTGYTGGSC QTLMDLCAQK PCPRNSHCLQ TGPSFHCLCL QGWTGPLCNL PLSSCQKAAL SQGIDVSSLC HNGGLCVDSG PSYFCHCPPG FQGSLCQDHV NPCESRPCQN GATCMAQPSG YLCQCAPGYD GQNCSKELDA CQSQPCHNHG TCTPKPGGFH CACPPGFVGL RCEGDVDECL DQPCHPTGTA ACHSLANAFY CQCLPGHTGQ WCEVEIDPCH SQPCFHGGTC EATAGSPLGF ICHCPKGFEG PTCSHRAPSC GFHHCHHGGL CLPSPKPGFP PRCACLSGYG GPDCLTPPAP KGCGPPSPCL YNGSCSETTG LGGPGFRCSC PHSSPGPRCQ KPGAKGCEGR SGDGACDAGC SGPGGNWDGG DCSLGVPDPW KGCPSHSRCW LLFRDGQCHP QCDSEECLFD GYDCETPPAC TPAYDQYCHD HFHNGHCEKG CNTAECGWDG GDCRPEDGDP EWGPSLALLV VLSPPALDQQ LFALARVLSL TLRVGLWVRK DRDGRDMVYP YPGARAEEKL GGTRDPTYQE RAAPQTQPLG KETDSLSAGF VVVMGVDLSR CGPDHPASRC PWDPGLLLRF LAAMAAVGAL EPLLPGPLLA VHPHAGTAPP ANQLPWPVLC SPVAGVILLA LGALLVLQLI RRRRREHGAL WLPPGFTRRP RTQSAPHRRR PPLGEDSIGL KALKPKAEVD EDGVVMCSGP EEGEEVGQAE ETGPPSTCQL WSLSGGCGAL PQAAMLTPPQ ESEMEAPDLD TRGPDGVTPL MSAVCCGEVQ SGTFQGAWLG CPEPWEPLLD GGACPQAHTV GTGETPLHLA ARFSRPTAAR RLLEAGANPN QPDRAGRTPL HAAVAADARE VCQLLLRSRQ TAVDARTEDG TTPLMLAARL AVEDLVEELI AAQADVGARD KWGKTALHWA AAVNNARAAR SLLQAGADKD AQDNREQTPL FLAAREGAVE VAQLLLGLGA ARELRDQAGL APADVAHQRN HWDLLTLLEG AGPPEARHKA TPGREAGPFP RARTVSVSVP PHGGGALPRC RTLSAGAGPR GGGACLQART WSVDLAARGG GAYSHCRSLS GVGAGGGPTP RGRRFSAGMR GPRPNPAIMR GRYGVAAGRG GRVSTDDWPC DWVALGACGS ASNIPIPPPC LTPSPERGSP QLDCGPPALQ EMPINQGGEG KK //