ID   A0A1R3UHJ7_HUMAN        Unreviewed;       251 AA.
AC   A0A1R3UHJ7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   13-FEB-2019, entry version 8.
DE   SubName: Full=Kallikrein M {ECO:0000313|EMBL:SFW93211.1};
DE   SubName: Full=Kallikrein-14 {ECO:0000313|Ensembl:ENSP00000156499};
GN   Name=KLK14 {ECO:0000313|Ensembl:ENSP00000156499};
GN   Synonyms=KLNM {ECO:0000313|EMBL:SFW93211.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:SFW93211.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000156499, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|EMBL:SFW93211.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28224083; DOI=10.1016/j.ymgmr.2017.01.009;
RA   Premzl M.;
RT   "Comparative genomic analysis of eutherian kallikrein genes.";
RL   Mol. Genet. Metab. Rep. 10:96-99(2017).
RN   [3] {ECO:0000313|Ensembl:ENSP00000497141}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2018) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSP00000156499}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2018) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
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DR   EMBL; AC011473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; LT631564; SFW93211.1; -; Genomic_DNA.
DR   RefSeq; NP_001298111.1; NM_001311182.1.
DR   RefSeq; NP_071329.2; NM_022046.5.
DR   UniGene; Hs.283925; -.
DR   Ensembl; ENST00000156499; ENSP00000156499; ENSG00000129437.
DR   Ensembl; ENST00000650543; ENSP00000497141; ENSG00000129437.
DR   GeneID; 43847; -.
DR   HGNC; HGNC:6362; KLK14.
DR   OpenTargets; ENSG00000129437; -.
DR   GeneTree; ENSGT00940000153621; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   ExpressionAtlas; A0A1R3UHJ7; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A1R3UHJ7,
KW   ECO:0000213|PeptideAtlas:A0A1R3UHJ7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    251       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017156846.
FT   DOMAIN       25    249       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
SQ   SEQUENCE   251 AA;  27453 MW;  9087953BAFA7ED25 CRC64;
     MFLLLTALQV LAIAMTQSQE DENKIIGGHT CTRSSQPWQA ALLAGPRRRF LCGGALLSGQ
     WVITAAHCGR PILQVALGKH NLRRWEATQQ VLRVVRQVTH PNYNSRTHDN DLMLLQLQQP
     ARIGRAVRPI EVTQACASPG TSCRVSGWGT ISSPIARYPA SLQCVNINIS PDEVCQKAYP
     RTITPGMVCA GVPQGGKDSC QGDSGGPLVC RGQLQGLVSW GMERCALPGY PGVYTNLCKY
     RSWIEETMRD K
//