ID A0A1D5RMN4_HUMAN Unreviewed; 695 AA. AC A0A1D5RMN4; DT 30-NOV-2016, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 1. DT 16-JAN-2019, entry version 18. DE RecName: Full=Follicle-stimulating hormone receptor {ECO:0000256|RuleBase:RU361222}; DE AltName: Full=Follitropin receptor {ECO:0000256|RuleBase:RU361222}; GN Name=FSHR {ECO:0000256|RuleBase:RU361222, GN ECO:0000313|Ensembl:ENSP00000384708}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000384708, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000384708, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000384708} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2016) to UniProtKB. CC -!- FUNCTION: G protein-coupled receptor for follitropin, the CC follicle-stimulating hormone. Through cAMP production activates CC the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. CC {ECO:0000256|RuleBase:RU361222}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|RuleBase:RU361222}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU361222}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC FSH/LSH/TSH subfamily. {ECO:0000256|RuleBase:RU361222}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC007189; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC079394; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC092533; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_000136.2; NM_000145.3. DR UniGene; Hs.1428; -. DR ProteinModelPortal; A0A1D5RMN4; -. DR SMR; A0A1D5RMN4; -. DR PRIDE; A0A1D5RMN4; -. DR Ensembl; ENST00000406846; ENSP00000384708; ENSG00000170820. DR GeneID; 2492; -. DR KEGG; hsa:2492; -. DR CTD; 2492; -. DR HGNC; HGNC:3969; FSHR. DR OpenTargets; ENSG00000170820; -. DR GeneTree; ENSGT00940000158952; -. DR KO; K04247; -. DR OMA; FGCYEMQ; -. DR OrthoDB; 257031at2759; -. DR ChiTaRS; FSHR; human. DR GenomeRNAi; 2492; -. DR Proteomes; UP000005640; Chromosome 2. DR ExpressionAtlas; A0A1D5RMN4; baseline and differential. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0005768; C:endosome; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004963; F:follicle-stimulating hormone receptor activity; IEA:Ensembl. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl. DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl. DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl. DR GO; GO:0071711; P:basement membrane organization; IEA:Ensembl. DR GO; GO:0009992; P:cellular water homeostasis; IEA:Ensembl. DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl. DR GO; GO:0045779; P:negative regulation of bone resorption; IEA:Ensembl. DR GO; GO:0031175; P:neuron projection development; IEA:Ensembl. DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl. DR GO; GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IEA:Ensembl. DR GO; GO:0001545; P:primary ovarian follicle growth; IEA:Ensembl. DR GO; GO:0060408; P:regulation of acetylcholine metabolic process; IEA:Ensembl. DR GO; GO:0033044; P:regulation of chromosome organization; IEA:Ensembl. DR GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl. DR GO; GO:0045670; P:regulation of osteoclast differentiation; IEA:Ensembl. DR GO; GO:0010640; P:regulation of platelet-derived growth factor receptor signaling pathway; IEA:Ensembl. DR GO; GO:0003073; P:regulation of systemic arterial blood pressure; IEA:Ensembl. DR GO; GO:0060009; P:Sertoli cell development; IEA:Ensembl. DR GO; GO:0060011; P:Sertoli cell proliferation; IEA:Ensembl. DR GO; GO:0035093; P:spermatogenesis, exchange of chromosomal proteins; IEA:Ensembl. DR GO; GO:0045056; P:transcytosis; IEA:Ensembl. DR GO; GO:0060065; P:uterus development; IEA:Ensembl. DR InterPro; IPR002272; FSH_rcpt. DR InterPro; IPR024635; GnHR_TM. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR002131; Gphrmn_rcpt_fam. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR000372; LRRNT. DR InterPro; IPR034298; TSHR/LHCGR/FSHR. DR PANTHER; PTHR24372; PTHR24372; 1. DR PANTHER; PTHR24372:SF5; PTHR24372:SF5; 1. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF12369; GnHR_trans; 1. DR Pfam; PF13306; LRR_5; 2. DR Pfam; PF01462; LRRNT; 1. DR PRINTS; PR01143; FSHRECEPTOR. DR PRINTS; PR00373; GLYCHORMONER. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM00013; LRRNT; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|RuleBase:RU361222}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU361222}; KW Membrane {ECO:0000256|RuleBase:RU361222}; KW Receptor {ECO:0000256|RuleBase:RU361222}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|RuleBase:RU361222}; KW Transducer {ECO:0000256|RuleBase:RU361222}; KW Transmembrane {ECO:0000256|RuleBase:RU361222}; KW Transmembrane helix {ECO:0000256|RuleBase:RU361222}. FT SIGNAL 1 17 {ECO:0000256|RuleBase:RU361222}. FT CHAIN 18 695 Follicle-stimulating hormone receptor. FT {ECO:0000256|RuleBase:RU361222}. FT /FTId=PRO_5008811855. FT TRANSMEM 367 387 Helical. {ECO:0000256|RuleBase:RU361222}. FT TRANSMEM 399 424 Helical. {ECO:0000256|RuleBase:RU361222}. FT TRANSMEM 444 465 Helical. {ECO:0000256|RuleBase:RU361222}. FT TRANSMEM 486 509 Helical. {ECO:0000256|RuleBase:RU361222}. FT TRANSMEM 529 554 Helical. {ECO:0000256|RuleBase:RU361222}. FT TRANSMEM 575 597 Helical. {ECO:0000256|RuleBase:RU361222}. FT TRANSMEM 609 629 Helical. {ECO:0000256|RuleBase:RU361222}. FT DOMAIN 379 626 G_PROTEIN_RECEP_F1_2. FT {ECO:0000259|PROSITE:PS50262}. SQ SEQUENCE 695 AA; 78238 MW; 4C5BC421014CD5BE CRC64; MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVLTKLRV IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP NLQYLLISNT GIKHLPDVHK IHSLQKVLLD IQDNINIHTI ERNSFVGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN LKKLRARSTY NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE VDYMTQARGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP DAFNPCEDIM GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL MCNLAFADLC IGIYLLLIAS VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV FASELSVYTL TAITLERWHT ITHAMQLDCK VQLRHAASVM VMGWIFAFAA ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL AFVVICGCYI HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS TVHNTHPRNG HCSSAPRVTS GSTYILVPLS HLAQN //