ID   A0A1B0GWE8_HUMAN        Unreviewed;       410 AA.
AC   A0A1B0GWE8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   16-JAN-2019, entry version 15.
DE   SubName: Full=Cathepsin D {ECO:0000313|Ensembl:ENSP00000490897};
GN   Name=CTSD {ECO:0000313|Ensembl:ENSP00000490897};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490897, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000490897, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [4] {ECO:0000313|Ensembl:ENSP00000490897}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01103,
CC       ECO:0000256|RuleBase:RU000454, ECO:0000256|SAAS:SAAS01079896}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01103}.
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DR   EMBL; AC068580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; A0A1B0GWE8; -.
DR   PeptideAtlas; A0A1B0GWE8; -.
DR   Ensembl; ENST00000636843; ENSP00000490897; ENSG00000117984.
DR   HGNC; HGNC:2529; CTSD.
DR   OpenTargets; ENSG00000117984; -.
DR   GeneTree; ENSGT00940000155733; -.
DR   ChiTaRS; CTSD; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   ExpressionAtlas; A0A1B0GWE8; baseline and differential.
DR   GO; GO:0005764; C:lysosome; IEA:InterPro.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd05490; Cathepsin_D2; 1.
DR   Gene3D; 2.40.70.10; -; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033144; Cathepsin_D.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR13683; PTHR13683; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   1: Evidence at protein level;
KW   Aspartyl protease {ECO:0000256|PROSITE-ProRule:PRU01103,
KW   ECO:0000256|RuleBase:RU000454};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00670207};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01103,
KW   ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01103,
KW   ECO:0000256|RuleBase:RU000454};
KW   Proteomics identification {ECO:0000213|EPD:A0A1B0GWE8,
KW   ECO:0000213|MaxQB:A0A1B0GWE8, ECO:0000213|PeptideAtlas:A0A1B0GWE8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    410       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008408691.
FT   DOMAIN       77    405       Peptidase A1.
FT                                {ECO:0000259|PROSITE:PS51767}.
FT   ACT_SITE     95     95       {ECO:0000256|PROSITE-ProRule:PRU01103}.
FT   ACT_SITE    293    293       {ECO:0000256|PROSITE-ProRule:PRU01103}.
SQ   SEQUENCE   410 AA;  44353 MW;  15528FF44B00EDFC CRC64;
     MQPSSLLPLA LCLLAAPASA LVRIPLHKFT SIRRTMSEVG GSVEDLIAKG PVSKYSQAVP
     AVTEGPIPEV LKNYMDYYGE IGIGTPPQCF TVVFDTGSSN LWVPSIHCKL LDIACWIHHK
     YNSDKSSTYV KNGTSFDIHY GSGSLSGYLS QDTVSVPCQS ASSASALGGV KVERQVFGEA
     TKQPGITFIA AKFDGILGMA YPRISVNNVL PVFDNLMQQK LVDQNIFSFY LSRDPDAQPG
     GELMLGGTDS KYYKGSLSYL NVTRKAYWQV HLDQVEVASG LTLCKEGCEA IVDTGTSLMV
     GPVDEVRELQ KAIGAVPLIQ GEYMIPCEKV STLPAITLKL GGKGYKLSPE DYTLKVSQAG
     KTLCLSGFMG MDIPPPSGPL WILGDVFIGR YYTVFDRDNN RVGFAEAARL
//