ID A0A1B0GW47_HUMAN Unreviewed; 284 AA. AC A0A1B0GW47; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 05-DEC-2018, entry version 12. DE SubName: Full=Neuronal acetylcholine receptor subunit alpha-7 {ECO:0000313|Ensembl:ENSP00000490773}; DE Flags: Fragment; GN Name=CHRNA7 {ECO:0000313|Ensembl:ENSP00000490773}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490773, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000490773, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., RA Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., RA Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human RT chromosome 15."; RL Nature 440:671-675(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000490773} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2016) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell CC membrane {ECO:0000256|SAAS:SAAS00569352}; Multi-pass membrane CC protein {ECO:0000256|SAAS:SAAS00569352}. Cell membrane CC {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00569391}. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) CC family. {ECO:0000256|RuleBase:RU000687, CC ECO:0000256|SAAS:SAAS00978283}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; ABBA01038340; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC058803; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC068448; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC079969; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456018; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456023; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF573652; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000637552; ENSP00000490773; ENSG00000175344. DR HGNC; HGNC:1960; CHRNA7. DR OpenTargets; ENSG00000175344; -. DR GeneTree; ENSGT00940000154617; -. DR ChiTaRS; CHRNA7; human. DR Proteomes; UP000005640; Chromosome 15. DR ExpressionAtlas; A0A1B0GW47; baseline and differential. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt. DR PANTHER; PTHR18945; PTHR18945; 2. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00254; NICOTINICR. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 3: Inferred from homology; KW Cell junction {ECO:0000256|SAAS:SAAS00103558}; KW Cell membrane {ECO:0000256|SAAS:SAAS00081553}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00103544}; KW Ion channel {ECO:0000256|SAAS:SAAS00032596}; KW Ion transport {ECO:0000256|SAAS:SAAS00032596}; KW Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00032596}; KW Membrane {ECO:0000256|SAAS:SAAS00081553, KW ECO:0000256|SAAS:SAAS00103558, ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00103558}; KW Receptor {ECO:0000256|SAAS:SAAS00103542}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Synapse {ECO:0000256|SAAS:SAAS00103558}; KW Transmembrane {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00032596}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 284 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008516963. FT TRANSMEM 207 231 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 238 259 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 27 205 Neur_chan_LBD. FT {ECO:0000259|Pfam:PF02931}. FT DOMAIN 213 284 Neur_chan_memb. FT {ECO:0000259|Pfam:PF02932}. FT NON_TER 284 284 {ECO:0000313|Ensembl:ENSP00000490773}. SQ SEQUENCE 284 AA; 32143 MW; AAA0E93E8119721D CRC64; MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVV TMRRRTLYYG LNLLIPCVLI SALALLVFLL PADSGEKISL GITVLLSLTV FMLLVAEIMP ATSDSVPLIA QYFASTMIIV GLSV //