ID A0A1B0GW14_HUMAN Unreviewed; 671 AA. AC A0A1B0GW14; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 16-JAN-2019, entry version 13. DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 2 {ECO:0000313|Ensembl:ENSP00000490734}; GN Name=KCNQ2 {ECO:0000313|Ensembl:ENSP00000490734}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490734, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000490734, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000490734} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the potassium channel family. CC {ECO:0000256|SAAS:SAAS00692852}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL121827; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL121829; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL353658; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456987; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; A0A1B0GW14; -. DR PeptideAtlas; A0A1B0GW14; -. DR Ensembl; ENST00000637193; ENSP00000490734; ENSG00000075043. DR HGNC; HGNC:6296; KCNQ2. DR OpenTargets; ENSG00000075043; -. DR GeneTree; ENSGT00940000160093; -. DR ChiTaRS; KCNQ2; human. DR Proteomes; UP000005640; Chromosome 20. DR ExpressionAtlas; A0A1B0GW14; baseline and differential. DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. DR InterPro; IPR020969; Ankyrin-G_BS. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR003947; K_chnl_volt-dep_KCNQ2. DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C. DR InterPro; IPR028325; VG_K_chnl. DR PANTHER; PTHR11537; PTHR11537; 1. DR PANTHER; PTHR11537:SF6; PTHR11537:SF6; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF03520; KCNQ_channel; 1. DR Pfam; PF11956; KCNQC3-Ank-G_bd; 1. DR PRINTS; PR00169; KCHANNEL. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Ion channel {ECO:0000256|SAAS:SAAS00417246}; KW Ion transport {ECO:0000256|SAAS:SAAS00417246}; KW Membrane {ECO:0000256|SAAS:SAAS00417245, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|SAAS:SAAS00417246}; KW Potassium channel {ECO:0000256|SAAS:SAAS00417246}; KW Potassium transport {ECO:0000256|SAAS:SAAS00417246}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A1B0GW14}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00417245, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00417245, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417246}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 671 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008408674. FT TRANSMEM 61 79 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 120 145 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 4 145 Ion_trans. {ECO:0000259|Pfam:PF00520}. FT DOMAIN 265 449 KCNQ_channel. {ECO:0000259|Pfam:PF03520}. SQ SEQUENCE 671 AA; 73916 MW; 408967F7F91D7834 CRC64; MVLIASIAVL AAGSQGNVFA TSALRSLRFL QILRMIRMDR RGGTWKLLGS VVYAHSKELV TAWYIGFLCL ILASFLVYLA EKGENDHFDT YADALWWGLI TLTTIGYGDK YPQTWNGRLL AATFTLIGVS FFALPAGILG SGFALKVQEQ HRQKHFEKRR NPAAGLIQSA WRFYATNLSR TDLHSTWQYY ERTVTVPMYR LIPPLNQLEL LRNLKSKSGL AFRKDPPPEP SPSQKVSLKD RVFSSPRGVA AKGKGSPQAQ TVRRSPSADQ SLEDSPSKVP KSWSFGDRSR ARQAFRIKGA ASRQNSEEAS LPGEDIVDDK SCPCEFVTED LTPGLKVSIR AVCVMRFLVS KRKFKESLRP YDVMDVIEQY SAGHLDMLSR IKSLQSRVDQ IVGRGPAITD KDRTKGPAEA ELPEDPSMMG RLGKVEKQVL SMEKKLDFLV NIYMQRMGIP PTETEAYFGA KEPEPAPPYH SPEDSREHVD RHGCIVKIVR SSSSTGQKNF SAPPAAPPVQ CPPSTSWQPQ SHPRQGHGTS PVGDHGSLVR IPPPPAHERS LSAYGGGNRA SMEFLRQEDT PGCRPPEGNL RDSDTSISIP SVDHEELERS FSGFSISQSK ENLDALNSCY AAVAPCAKVR PYIAEGESDT DSDLCTPCGP PPRSATGEGP FGDVGWAGPR K //