ID   A0A1B0GVI2_HUMAN        Unreviewed;       223 AA.
AC   A0A1B0GVI2;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   05-DEC-2018, entry version 12.
DE   SubName: Full=Voltage-dependent L-type calcium channel subunit alpha-1D {ECO:0000313|Ensembl:ENSP00000490523};
DE   Flags: Fragment;
GN   Name=CACNA1D {ECO:0000313|Ensembl:ENSP00000490523};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490523, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000490523, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000490523}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2016) to UniProtKB.
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DR   EMBL; AC005905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC012467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC132810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; A0A1B0GVI2; -.
DR   Ensembl; ENST00000638129; ENSP00000490523; ENSG00000157388.
DR   HGNC; HGNC:1391; CACNA1D.
DR   OpenTargets; ENSG00000157388; -.
DR   GeneTree; ENSGT00940000154839; -.
DR   ChiTaRS; CACNA1D; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   ExpressionAtlas; A0A1B0GVI2; baseline and differential.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 2.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00084701, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    223       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008408755.
FT   TRANSMEM     69     87       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     99    117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    141       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       65    121       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      122    223       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000490523}.
FT   NON_TER     223    223       {ECO:0000313|Ensembl:ENSP00000490523}.
SQ   SEQUENCE   223 AA;  26175 MW;  E28EFA7FC3A46282 CRC64;
     FFMMNIFVGF VIVTFQEQGE KEYKNCELDK NQRQCVEYAL KARPLRRYIP KNPYQYKFWY
     VVNSSPFEYM MFVLIMLNTL CLAMQHYEQS KMFNDAMDIL NMVFTGVFTV EMVLKVIAFK
     PKALPYVALL IAMLFFIYAV IGMQMFGKVA MRDNNQINRN NNFQTFPQAV LLLFRCATGE
     AWQEIMLACL PGKLCDPESD YNPGEEYTCG SNFAIVYFIS FYM
//