ID   PRS51_HUMAN             Reviewed;         220 AA.
AC   A0A1B0GVH4;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 1.
DT   16-JAN-2019, entry version 14.
DE   RecName: Full=Serine protease-like protein 51 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=PRSS51 {ECO:0000312|HGNC:HGNC:37321};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
CC   -!- CAUTION: Lacks essential residues of the catalytic triad and is
CC       therefore predicted to have no protease activity. {ECO:0000305}.
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DR   EMBL; AC104964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.675958; -.
DR   BioMuta; PRSS51; -.
DR   PeptideAtlas; A0A1B0GVH4; -.
DR   Ensembl; ENST00000636217; ENSP00000490515; ENSG00000253649.
DR   GeneCards; PRSS51; -.
DR   HGNC; HGNC:37321; PRSS51.
DR   neXtProt; NX_A0A1B0GVH4; -.
DR   OpenTargets; ENSG00000253649; -.
DR   GeneTree; ENSGT00940000156020; -.
DR   OMA; MICAWNE; -.
DR   ChiTaRS; PRSS51; human.
DR   PRO; PR:A0A1B0GVH4; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   ExpressionAtlas; A0A1B0GVH4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   Pfam; PF00089; Trypsin; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     16       {ECO:0000255}.
FT   CHAIN        17    220       Serine protease-like protein 51.
FT                                {ECO:0000255}.
FT                                /FTId=PRO_5008408658.
FT   DOMAIN       23    220       Peptidase S1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00274}.
FT   CARBOHYD     33     33       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     92     92       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     64     80       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   DISULFID    157    170       {ECO:0000255|PROSITE-ProRule:PRU00274}.
SQ   SEQUENCE   220 AA;  25576 MW;  FC84299A348126D2 CRC64;
     MFQLLIPLLL ALKGHAQDNP ENVQCGHRPA FPNSSWLPFH ERLQVQNGEC PWQVSIQMSR
     KHLCGGSILH WWWVLTAAHC FRRTLLDMAV VNVTVVMGTR TFSNIHSERK QVQKEEERTW
     DWCWMAQWVT TNGYDQYDDL NMHLEKLRVV QISRKECAKR INQLSRNMIC AWNEPGTNGI
     FKVLTPAQPP PPSRETVGHL WFVLFMEPRD SSKWVSSVGA
//